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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $1,780 | Backorder |
Description | 6,7,4'-Trihydroxyflavanone possesses various pharmacological activities, including anti-rheumatic, anti-ischemic, anti-inflammatory, anti-osteoclastogenic, and protective effects against METH-induced deactivation of T cells. 6,7,4'-Trihydroxyflavanone can be used for studies about the treatment of METH-addicts suffering from neurodegenerative diseases. |
In vitro | 6,7,4'-Trihydroxyflavanone (40 μM) did not lead to cytotoxicity, but attenuated METH-induced neurotoxicity by modulating the expression of apoptosis-related proteins, METH-induced oxidative stress, and PI3K/Akt/mTOR phosphorylation in METH-exposed SH-SY5y cells. 6,7,4'-Trihydroxyflavanone induced Nrf2 nuclear translocation and HO-1 expression. The induction of HO-1 by 6,7,4'-Trihydroxyflavanone attenuates METH-induced neurotoxicity[1]. |
In vivo | 6,7,4'-Trihydroxyflavanone (20 and 50 mg/kg; orally) alleviates dextran sulfate sodium (DSS)-induced colitis by modulating the activity of T cells and colon cells in vivo including a reduction in body weight, shrinkage of the colon, and enhanced expression of pro-inflammatory cytokines in the colon and mesenteric lymph nodes[2]. |
Molecular Weight | 272.25 |
Formula | C15H12O5 |
Cas No. | 189689-31-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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