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6β-Prostaglandin I1

Name: 6β-Prostaglandin I1
Brand: TargetMol
SKU: T36239
Rating: 4.5 (1 reviews)

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Catalog No. T36239Cas No. 62770-50-7

Alias 6β-Prostaglandin I1

6β-PGI1 is a stable PGI2 analog resistant to hydrolysis in aqueous solutions. 6β-PGI1 has a much longer half-life than PGI2, but a greatly reduced molar potency for receptor mediated function. 6β-PGI1 has a Kact for adenylate cyclase in NCB-20 cells of 4.2 μM compared with 18 nM for PGI2. The potency for vasodilation and inhibition of platelet aggregation is about 1% of PGI2.

6β-Prostaglandin I1

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Catalog No. T36239Alias 6β-Prostaglandin I1Cas No. 62770-50-7

Pack Size	Price	Availability
1 mg	Inquiry	35 days
5 mg	Inquiry	35 days
10 mg	Inquiry	35 days

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Product Introduction

Bioactivity

Description	6β-PGI1 is a stable PGI2 analog resistant to hydrolysis in aqueous solutions. 6β-PGI1 has a much longer half-life than PGI2, but a greatly reduced molar potency for receptor mediated function. 6β-PGI1 has a Kact for adenylate cyclase in NCB-20 cells of 4.2 μM compared with 18 nM for PGI2. The potency for vasodilation and inhibition of platelet aggregation is about 1% of PGI2.
Alias	6β-Prostaglandin I1

Chemical Properties

Molecular Weight	354.487
Formula	C₂₀H₃₄O₅
Cas No.	62770-50-7

Storage & Solubility Information

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMF: >10 (from 6b-PGI1), Sonication is recommended. DMSO: >5 (from 6b-PGI1), Sonication is recommended. PBS (pH 7.2): >80 μg (from 6b-PGI1), Sonication is recommended. Ethanol: >20 mg/mL (from 6b-PGI1), Sonication is recommended.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

6β Prostaglandin I16β-Prostaglandin I-16b-Prostaglandin I16βProstaglandin I16beta-Prostaglandin I1