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6-Bromohexylphosphonic acid

Catalog No. T14056Cas No. 133345-66-1

6-Bromohexylphosphonic acid, an alkyl chain-based linker, is commonly used in the synthesis of PROTACs (proteolysis targeting chimeras) [1].

6-Bromohexylphosphonic acid

6-Bromohexylphosphonic acid

Catalog No. T14056Cas No. 133345-66-1
6-Bromohexylphosphonic acid, an alkyl chain-based linker, is commonly used in the synthesis of PROTACs (proteolysis targeting chimeras) [1].
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Product Introduction

Bioactivity
Description
6-Bromohexylphosphonic acid, an alkyl chain-based linker, is commonly used in the synthesis of PROTACs (proteolysis targeting chimeras) [1].
In vitro
PROTACs consist of two ligands linked together: one binding to an E3 ubiquitin ligase and the other to a target protein. They leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Chemical Properties
Molecular Weight245.05
FormulaC6H14BrO3P
Cas No.133345-66-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Keywords

6Bromohexylphosphonic acid6-Bromohexylphosphonic acid6 Bromohexylphosphonic acid
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