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6-Hydroxypyridin-3-ylboronic Acid

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Catalog No. T35533Cas No. 903899-13-8

6-Hydroxypyridin-3-ylboronic acid is a heterocyclic building block.1,2It has been used in the synthesis of non-nucleoside inhibitors of hepatitis C virus (HCV) RNA-dependent RNA polymerase nonstructural protein 5B (NS5B).16-Hydroxypyridin-3-ylboronic acid has also been used in the synthesis of mammalian target of rapamycin (mTOR) inhibitors.2

6-Hydroxypyridin-3-ylboronic Acid

6-Hydroxypyridin-3-ylboronic Acid

😃Good
Catalog No. T35533Cas No. 903899-13-8
6-Hydroxypyridin-3-ylboronic acid is a heterocyclic building block.1,2It has been used in the synthesis of non-nucleoside inhibitors of hepatitis C virus (HCV) RNA-dependent RNA polymerase nonstructural protein 5B (NS5B).16-Hydroxypyridin-3-ylboronic acid has also been used in the synthesis of mammalian target of rapamycin (mTOR) inhibitors.2
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100 mg$155 35 days
250 mg$338 35 days
500 mg$598 35 days
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Product Introduction

Bioactivity
Description
6-Hydroxypyridin-3-ylboronic acid is a heterocyclic building block.1,2It has been used in the synthesis of non-nucleoside inhibitors of hepatitis C virus (HCV) RNA-dependent RNA polymerase nonstructural protein 5B (NS5B).16-Hydroxypyridin-3-ylboronic acid has also been used in the synthesis of mammalian target of rapamycin (mTOR) inhibitors.2
1.Hendricks, R.T., Spencer, S.R., Blake, J.F., et al.3-Hydroxyisoquinolines as inhibitors of HCV NS5b RNA-dependent RNA polymeraseBioorg. Med. Chem. Lett.19(2)410-414(2009) 2.Verheijen, J.C., Richard, D.J., Curran, K., et al.Discovery of 4-morpholino-6-aryl-1H-pyrazolo[3,4-d]pyrimidines as highly potent and sselective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): Optimization of the 6-aryl substituentJ. Med. Chem.52(24)8010-8024(2009)
Chemical Properties
Molecular Weight138.92
FormulaC5H6BNO3
Cas No.903899-13-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO:PBS (pH 7.2) (1:5): 0.16 mg/mL (1.15 mM), Sonication is recommended.
DMSO: 30 mg/mL (215.95 mM), Sonication is recommended.
Ethanol: 1 mg/mL (7.2 mM), Sonication is recommended.
DMF: 30 mg/mL (215.95 mM), Sonication is recommended.
Solution Preparation Table
Ethanol/DMSO/DMF
1mg5mg10mg50mg
5 mM1.4397 mL7.1984 mL14.3968 mL71.9839 mL
DMSO/DMF
1mg5mg10mg50mg
10 mM0.7198 mL3.5992 mL7.1984 mL35.9919 mL
20 mM0.3599 mL1.7996 mL3.5992 mL17.9960 mL
50 mM0.1440 mL0.7198 mL1.4397 mL7.1984 mL
100 mM0.0720 mL0.3599 mL0.7198 mL3.5992 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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