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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $143 | 35 days | |
5 mg | $623 | 35 days | |
10 mg | $1,090 | 35 days |
Description | 9(Z),11(E),13(E)-Octadecatrienoic Acid (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil. α-ESA is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats. It has shown potential as a tumor growth suppressor. In colon cancer Caco-2 cells, α-ESA induced apoptosis through up-regulation of GADD45, p53, and PPARγ. In DLD-1 cells supplemented with α-ESA, apoptosis was induced via lipid peroxidation with an EC50 of 20 μM. It also inhibits DNA polymerases and topoisomerases with IC50s ranging from ~5-20 μM for different isoforms of the enzymes. |
Molecular Weight | 278.436 |
Formula | C18H30O2 |
Cas No. | 506-23-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility Information | Ethanol: 30 mg/mL Ethanol:PBS (pH 7.2)(1:10): 0.5 mg/mL DMF: 30 mg/mL DMSO: 30 mg/mL |
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