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9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2

9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2
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9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2

Catalog No. T36829Cas No. 61263-35-2
9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2 (Meteneprost) is a potent analog of prostaglandin E2 with an extended half-life in vivo. In combination with various other prostaglandin derivatives, it results in the termination of first trimester pregnancy in monkeys. A single intramuscular injection containing 0.5 mg of meteneprost and 7.5 mg of 17-phenyl trinor PGF1α is very effective in terminating early pregnancy. This prostaglandin mixture is ineffective on monkeys in their third trimester of pregnancy. Meteneprost, when compared to PGE2 and PGF1α, in monkey and rat, does not result in unwanted side effects such as fever or gastrointestinal problems.
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500 μg$12835 days
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Product Introduction

Bioactivity
Description
9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2 (Meteneprost) is a potent analog of prostaglandin E2 with an extended half-life in vivo. In combination with various other prostaglandin derivatives, it results in the termination of first trimester pregnancy in monkeys. A single intramuscular injection containing 0.5 mg of meteneprost and 7.5 mg of 17-phenyl trinor PGF1α is very effective in terminating early pregnancy. This prostaglandin mixture is ineffective on monkeys in their third trimester of pregnancy. Meteneprost, when compared to PGE2 and PGF1α, in monkey and rat, does not result in unwanted side effects such as fever or gastrointestinal problems.
Alias9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2
Chemical Properties
Molecular Weight378.553
FormulaC23H38O4
Cas No.61263-35-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: >100 mg/mL (from PGE2)
PBS (pH 7.2): >5 mg/mL (from PGE2)
Ethanol: >100 mg/mL (from PGE2)
DMF: >100 mg/mL (from PGE2)

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Preparation method for in vivo formula: Take 50 μLDMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μLTween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify.
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