Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

A-887826

Catalog No. T10209Cas No. 1266212-81-0

A-887826 is a selective, orally bioavailable, and voltage-dependent Na(v1.8) channel blocker (IC50: 11 nM). It attenuates neuropathic tactile allodynia in vivo.

A-887826

A-887826

Catalog No. T10209Cas No. 1266212-81-0
A-887826 is a selective, orally bioavailable, and voltage-dependent Na(v1.8) channel blocker (IC50: 11 nM). It attenuates neuropathic tactile allodynia in vivo.
TargetMol
Product information is being updated, if you want to purchase, please click the bulk custom button.
Bulk & Custom
Questions
View More
Contact us for more batch information
Resource Download
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
A-887826 is a selective, orally bioavailable, and voltage-dependent Na(v1.8) channel blocker (IC50: 11 nM). It attenuates neuropathic tactile allodynia in vivo.
Targets&IC50
Nav1.8:11 nM
In vitro
A-887826 exhibits variable potency in blocking sodium channels, being approximately three times less effective against Na(v)1.2 channels, about ten times less effective in blocking tetrodotoxin-sensitive sodium (TTX-S Na(+)) currents, and over thirty times less effective against Na(v)1.5 channels. However, it demonstrates significant efficacy in blocking tetrodotoxin-resistant sodium (TTX-R Na(+)) currents with an IC50 of 8 nM in small diameter rat dorsal root ganglion (DRG) neurons, acting in a voltage-dependent manner. It potently reduces both evoked and spontaneous action potential firing in DRG neurons at depolarized potentials and in neurons from rats with inflammation due to complete Freund's adjuvant. A-887826, at a concentration of 100 nM, specifically alters the voltage-dependent inactivation of TTX-R currents by about 4mV, without impacting voltage-dependent activation, and does not show frequency-dependent inhibition.
In vivo
A-887826 (3-30 mg/kg; p.o.; 1-hour pre-treatment) significantly reduces tactile allodynia in a rat neuropathic pain model.
Animal Research
Animal Model: Male Spraguee Dawley rats (200-300 g). Dosage: 3 mg/kg, 10 mg/kg, 30 mg/kg. Administration: p.o.; 1 hour before testing; fourteen days after L5-L6 spinal nerve ligation
Chemical Properties
Molecular Weight480.99
FormulaC26H29ClN4O3
Cas No.1266212-81-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy A-887826 | purchase A-887826 | A-887826 cost | order A-887826 | A-887826 chemical structure | A-887826 in vivo | A-887826 in vitro | A-887826 formula | A-887826 molecular weight