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Abatacept

Abatacept
Abatacept (CTLA4Ig) is a soluble fusion protein composed of the extracellular domain of human CTLA4 and a fragment of the Fc portion of human IgG1 (hinge and CH2 and 3 domains), functioning as a selective T-cell co-stimulation modulator and a protein drug for autoimmune diseases.
Catalog No. T10218Cas No. 332348-12-6
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Abatacept

Catalog No. T10218Cas No. 332348-12-6
Abatacept (CTLA4Ig) is a soluble fusion protein composed of the extracellular domain of human CTLA4 and a fragment of the Fc portion of human IgG1 (hinge and CH2 and 3 domains), functioning as a selective T-cell co-stimulation modulator and a protein drug for autoimmune diseases.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction

Bioactivity
Description
Abatacept (CTLA4Ig) is a soluble fusion protein composed of the extracellular domain of human CTLA4 and a fragment of the Fc portion of human IgG1 (hinge and CH2 and 3 domains), functioning as a selective T-cell co-stimulation modulator and a protein drug for autoimmune diseases.
In vivo
Abatacept reduces paw edema, with the SC multiple-dose group showing significantly greater reduction (tobs = 2.50) compared to the IV dose group. It exhibits linear PK across studied doses, with an NCA clearance (CL) of 20.8 mL/day/kg, volume (Vss) of 146 mL/kg, and bioavailability (F) of the SC dose at 57.7% [2]. Abatacept (oral; 10 mg/kg; every 2 days) also reduces the proportion of activated T cells (CD44highCD62L–) and inhibits the up-regulation of ICOS and CD71 in homozygous DO11.10 RAG-2–/–BALB/c (H-2d/d) mice [3].
Animal Research
Animal Model: Male Lewis rats (6-9 weeks old) with weights of 150-175 g. Dosage: 10 mg/kg (i.v.), 20 mg/kg (s.c. single-dose), 20 mg/kg (SC Multiple-dose) on day 21 with 10 mg/kg SC doses on days 23, 25, 27, and 29. Administration: i.v. or s.c. [2]
AliasCTLA4lg
Chemical Properties
Cas No.332348-12-6
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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