Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Amelubant (BIIL 284) is a prodrug of active metabolites BIIL 260 and BIIL 315. Anti-inflammatory activity[1]. Amelubant (BIIL 284) is a potent, oral and long acting LTB4 receptor antagonist, negligibly binds to LTB4 receptor, with Kis of 221 nM and 230 nM in vital cells and membranes.
Description | Amelubant (BIIL 284) is a prodrug of active metabolites BIIL 260 and BIIL 315. Anti-inflammatory activity[1]. Amelubant (BIIL 284) is a potent, oral and long acting LTB4 receptor antagonist, negligibly binds to LTB4 receptor, with Kis of 221 nM and 230 nM in vital cells and membranes. |
Targets&IC50 | LTB4:221 nM (ki)( in vital human granulocytes), LTB4:230 nM (ki)( in cell membranes) |
In vitro | Amelubant is a prodrug of active metabolites BIIL 260 and BIIL 315. Which are reversible and competitive LTB4 receptor antagonists, with Kis of 1.4, 1.1 nM and 1.7, 1.9 nM in vital cells and membranes, respectively[1]. |
Synonyms | BIIL 284 |
Molecular Weight | 538.63 |
Formula | C33H34N2O5 |
CAS No. | 346735-24-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Amelubant 346735-24-8 Immunology/Inflammation LTR BIIL 284 BIIL-284 BIIL284 inhibitor inhibit