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BAY-7598 is a potent, selective, and orally bioavailable MMP12 inhibitor (IC50s: 0.085, 0.67, and 1.1 nM for human/murine/rat MMP12).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $2,720 | 10-14 weeks | |
50 mg | $3,580 | 10-14 weeks | |
100 mg | $4,900 | 10-14 weeks |
Description | BAY-7598 is a potent, selective, and orally bioavailable MMP12 inhibitor (IC50s: 0.085, 0.67, and 1.1 nM for human/murine/rat MMP12). |
Targets&IC50 | MMP12 (murine):0.67 nM , MMP12 (human):0.085 nM , MMP12 (rat):1.1 nM |
In vitro | BAY-7598 inhibits human MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP13, MMP14, and MMP16 (IC50s: 44, 360, 600, 15, 460, 12, 67, 250, and 940 nM), murine MMP2, MMP3, MMP7, MMP8, and MMP9 (IC50s: 45, 270, 130, 54, and 210 nM), and rat MMP2, MMP8, and MMP9 (IC50s: 45, 67, and 1000 nM). |
In vivo | BAY-7598 exhibits a moderate terminal elimination half-life, with t1/2 values of 4.1 hours in mice administered orally at 5.0 mg/kg and 4.6 hours in mice administered intravenously at 0.3 mg/kg [mouse (5.0 mg/kg, p.o.), mouse (0.3 mg/kg, iv), respectively]. |
Molecular Weight | 505.56 |
Formula | C28H31N3O6 |
Cas No. | 1816257-74-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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