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BAY-7598

Catalog No. T10474Cas No. 1816257-74-5

BAY-7598 is a potent, selective, and orally bioavailable MMP12 inhibitor (IC50s: 0.085, 0.67, and 1.1 nM for human/murine/rat MMP12).

BAY-7598

BAY-7598

Catalog No. T10474Cas No. 1816257-74-5
BAY-7598 is a potent, selective, and orally bioavailable MMP12 inhibitor (IC50s: 0.085, 0.67, and 1.1 nM for human/murine/rat MMP12).
Pack SizePriceAvailabilityQuantity
25 mg$2,72010-14 weeks
50 mg$3,58010-14 weeks
100 mg$4,90010-14 weeks
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Product Introduction

Bioactivity
Description
BAY-7598 is a potent, selective, and orally bioavailable MMP12 inhibitor (IC50s: 0.085, 0.67, and 1.1 nM for human/murine/rat MMP12).
Targets&IC50
MMP12 (murine):0.67 nM , MMP12 (human):0.085 nM , MMP12 (rat):1.1 nM
In vitro
BAY-7598 inhibits human MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP13, MMP14, and MMP16 (IC50s: 44, 360, 600, 15, 460, 12, 67, 250, and 940 nM), murine MMP2, MMP3, MMP7, MMP8, and MMP9 (IC50s: 45, 270, 130, 54, and 210 nM), and rat MMP2, MMP8, and MMP9 (IC50s: 45, 67, and 1000 nM).
In vivo
BAY-7598 exhibits a moderate terminal elimination half-life, with t1/2 values of 4.1 hours in mice administered orally at 5.0 mg/kg and 4.6 hours in mice administered intravenously at 0.3 mg/kg [mouse (5.0 mg/kg, p.o.), mouse (0.3 mg/kg, iv), respectively].
Chemical Properties
Molecular Weight505.56
FormulaC28H31N3O6
Cas No.1816257-74-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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