Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BAY-899 is an orally active and selective antagonist of the luteinizing hormone receptor (LH-R), exhibiting IC50 values of 185 nM and 46 nM for human LH (hLH) and rat LH (rLH) respectively. In vivo studies have demonstrated that BAY-899 effectively reduces sex hormone levels[1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | Inquiry | |
50 mg | 6-8 weeks | Inquiry | |
100 mg | 6-8 weeks | Inquiry |
Description | BAY-899 is an orally active and selective antagonist of the luteinizing hormone receptor (LH-R), exhibiting IC50 values of 185 nM and 46 nM for human LH (hLH) and rat LH (rLH) respectively. In vivo studies have demonstrated that BAY-899 effectively reduces sex hormone levels[1]. |
Targets&IC50 | LH (human):185 nM , LH (rat):46nM |
In vivo | BAY-899, administered orally at a dosage of 12.5 mg/kg/day for 8 days, effectively reduces serum estradiol levels in intact female rats. In both female and male Wistar rats, BAY-899 demonstrates a half-life (t 1/2) of 11 hours when given intravenously (iv) at 0.5 mg/kg and 12 hours when administered orally (po) at 2 mg/kg. Additionally, the maximum concentration (Cmax) achieved is 0.97 kg/L for the intravenous route and 0.24 kg/L for the oral route. |
Molecular Weight | 459.45 |
Formula | C25H19F2N5O2 |
CAS No. | 2471967-92-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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BAY-899 2471967-92-5 Others BAY899 BAY 899 inhibitor inhibit