Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CMLD012612 is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. It inhibits cell translation and is cytotoxic to NIH/3T3 cells (IC50: 2 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | CMLD012612 is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. It inhibits cell translation and is cytotoxic to NIH/3T3 cells (IC50: 2 nM). |
In vitro | The primary action of CMLD012612 hinges on its interaction with eIF4A1, as demonstrated by eIF4A1em1jp cells exhibiting at least a 10-fold increased resistance compared to the original NIH/3T3 cells. This resistance is diminished at higher concentrations of CMLD012612, possibly because of the presence of wild-type eIF4A2 in the eIF4A1em1jp cells. |
In vivo | When administered to mice bearing myr-Akt/Em-Myc lymphomas, CMLD012612 (0.2 mg/kg; i.p.; daily; for 5 days; female C57BL/6 mice) treatment effectively synergizes with Doxorubicin, leading to complete tumor loss. CMLD012612 (0.5 mg/kg; i.p.; for 3 hours; female C57BL/6 mice) treatment effectively suppresses liver polysomes 3 hours after injection. |
Molecular Weight | 559.61 |
Formula | C31H33N3O7 |
CAS No. | 2368900-35-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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CMLD012612 2368900-35-8 Others CMLD 012612 CMLD-012612 inhibitor inhibit