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COH34

Catalog No. T10859Cas No. 906439-72-3
Alias 1-[(E)-(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-ol

COH34 (1-[(E)-(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-ol) is a selective inhibitor of PARG with an IC50 of 0.37 nM and a Kd of 0.547 μM. COH34 prolongs PARylation at DNA lesions and traps DNA repair factors.

COH34

COH34

Purity: 98.21%
Catalog No. T10859Alias 1-[(E)-(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-olCas No. 906439-72-3
COH34 (1-[(E)-(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-ol) is a selective inhibitor of PARG with an IC50 of 0.37 nM and a Kd of 0.547 μM. COH34 prolongs PARylation at DNA lesions and traps DNA repair factors.
Pack SizePriceAvailabilityQuantity
1 mg$135In Stock
5 mg$289In Stock
10 mg$455In Stock
25 mg$753In Stock
50 mg$1,060In Stock
100 mg$1,430In Stock
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Purity:98.21%
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Product Introduction

Bioactivity
Description
COH34 (1-[(E)-(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-ol) is a selective inhibitor of PARG with an IC50 of 0.37 nM and a Kd of 0.547 μM. COH34 prolongs PARylation at DNA lesions and traps DNA repair factors.
Targets&IC50
PARG:0.37 nM
In vitro
COH34 potently inhibits PARP inhibitor-resistant cancer cells[1].
In vivo
COH34 shows antitumor activity in xenograft mouse cancer models[1].
Alias1-[(E)-(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-ol
Chemical Properties
Molecular Weight293.38
FormulaC18H15NOS
Cas No.906439-72-3
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 15 mg/mL (51.1 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.4085 mL17.0427 mL34.0855 mL170.4274 mL
5 mM0.6817 mL3.4085 mL6.8171 mL34.0855 mL
10 mM0.3409 mL1.7043 mL3.4085 mL17.0427 mL
20 mM0.1704 mL0.8521 mL1.7043 mL8.5214 mL
50 mM0.0682 mL0.3409 mL0.6817 mL3.4085 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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