store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
COH34 (1-[(E)-(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-ol) is a selective inhibitor of PARG with an IC50 of 0.37 nM and a Kd of 0.547 μM. COH34 prolongs PARylation at DNA lesions and traps DNA repair factors.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 135.00 | |
5 mg | In stock | $ 289.00 | |
10 mg | In stock | $ 455.00 | |
25 mg | In stock | $ 753.00 | |
50 mg | In stock | $ 1,060.00 | |
100 mg | In stock | $ 1,430.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 273.00 |
Description | COH34 (1-[(E)-(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-ol) is a selective inhibitor of PARG with an IC50 of 0.37 nM and a Kd of 0.547 μM. COH34 prolongs PARylation at DNA lesions and traps DNA repair factors. |
Targets&IC50 | PARG:0.37 nM |
In vitro | COH34 potently inhibits PARP inhibitor-resistant cancer cells[1]. |
In vivo | COH34 shows antitumor activity in xenograft mouse cancer models[1]. |
Synonyms | 1-[(E)-(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-ol |
Molecular Weight | 293.38 |
Formula | C18H15NOS |
CAS No. | 906439-72-3 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 15 mg/mL (51.1 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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COH34 906439-72-3 Others COH-34 1-[(E)-(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-ol COH 34 inhibitor inhibit