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COH34 (1-[(E)-(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-ol) is a selective inhibitor of PARG with an IC50 of 0.37 nM and a Kd of 0.547 μM. COH34 prolongs PARylation at DNA lesions and traps DNA repair factors.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $135 | In Stock | |
5 mg | $289 | In Stock | |
10 mg | $455 | In Stock | |
25 mg | $753 | In Stock | |
50 mg | $1,060 | In Stock | |
100 mg | $1,430 | In Stock |
Description | COH34 (1-[(E)-(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-ol) is a selective inhibitor of PARG with an IC50 of 0.37 nM and a Kd of 0.547 μM. COH34 prolongs PARylation at DNA lesions and traps DNA repair factors. |
Targets&IC50 | PARG:0.37 nM |
In vitro | COH34 potently inhibits PARP inhibitor-resistant cancer cells[1]. |
In vivo | COH34 shows antitumor activity in xenograft mouse cancer models[1]. |
Alias | 1-[(E)-(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-ol |
Molecular Weight | 293.38 |
Formula | C18H15NOS |
Cas No. | 906439-72-3 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 15 mg/mL (51.1 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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