Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CPPG is a potent antagonist of group II/III mGlu receptors. CPPG exhibits some selectivity (approximately 20 fold) for group III (IC50: 2.2 nM) over group II (IC50: 46.2 nM) mGlu receptors in the rat cerebral cortex.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | 35 days | $ 93.00 | |
5 mg | 35 days | $ 270.00 | |
10 mg | 35 days | $ 488.00 | |
25 mg | 35 days | $ 1,100.00 |
Description | CPPG is a potent antagonist of group II/III mGlu receptors. CPPG exhibits some selectivity (approximately 20 fold) for group III (IC50: 2.2 nM) over group II (IC50: 46.2 nM) mGlu receptors in the rat cerebral cortex. |
Targets&IC50 | mGlu receptor (Group II):46.2 nM (IC50), mGlu receptor (Group III):2.2 nM (IC50) |
In vitro | CPPG ((RS)-CPPG) potently reversed both L-AP4 (IC50: 2.2 nM)- and L-CCG-I (IC50: 46.2 nM) -mediated inhibition of forskolin-stimulated cyclic AMP accumulation in adult rat cortical slices. CPPG has weak effects at the group I mGlu receptors in both the neonatal rat cortex and cultured cerebellar granule cells. |
Synonyms | (RS)-CPPG |
Molecular Weight | 271.21 |
Formula | C11H14NO5P |
CAS No. | 183364-82-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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CPPG 183364-82-1 Others (RS)-CPPG inhibitor inhibit