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CXCR3 Antagonist 6c

Name: CXCR3 Antagonist 6c
Brand: TargetMol
SKU: T36982
Price: 36 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T36982Cas No. 870998-13-3

CXCR3 Antagonist 6c

😃Good

Catalog No. T36982Cas No. 870998-13-3

Pack Size	Price	Availability
1 mg	$123	35 days
5 mg	$540	35 days
10 mg	$890	35 days

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description

CXCR3 antagonist 6c is an antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3).1It inhibits calcium mobilization induced by chemokine (C-X-C motif) ligand 11 (CXCL11) in HEK293 cells expressing the human receptor (IC50= 0.06 μM). It is selective for CXCR3 over a panel of 14 human G protein-coupled receptors at 10 μM. CXCR3 antagonist 6c inhibits CXCR3-mediated migration of isolated human T cells (IC50= ~100 nM).
1.Cole, A.G., Stroke, I.L., Brescia, M.-R., et al.Identification and initial evaluation of 4-N-aryl-[1,4]diazepane ureas as potent CXCR3 antagonistsBioorg. Med. Chem. Lett.16(1)200-203(2006)

Chemical Properties

Molecular Weight	616.97
Formula	C₃₀H₃₂Cl₃N₅O₃
Cas No.	870998-13-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: >100 mM

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6208 mL	8.1041 mL	16.2082 mL	81.0412 mL
5 mM	0.3242 mL	1.6208 mL	3.2416 mL	16.2082 mL
10 mM	0.1621 mL	0.8104 mL	1.6208 mL	8.1041 mL
20 mM	0.0810 mL	0.4052 mL	0.8104 mL	4.0521 mL
50 mM	0.0324 mL	0.1621 mL	0.3242 mL	1.6208 mL
100 mM	0.0162 mL	0.0810 mL	0.1621 mL	0.8104 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

CXCR-3 Antagonist 6cCXCR3 Antagonist 6c