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CYM 9484
🥰Excellent
Catalog No. T10921Cas No. 1383478-94-1
CYM 9484 is a selective and potent neuropeptide Y (NPY) Y2 receptor antagonist with an IC50 value of 19 nM.
CYM 9484
🥰Excellent
Catalog No. T10921Cas No. 1383478-94-1
CYM 9484 is a selective and potent neuropeptide Y (NPY) Y2 receptor antagonist with an IC50 value of 19 nM.
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Product Introduction
Bioactivity
Chemical Properties
| Description | CYM 9484 is a selective and potent neuropeptide Y (NPY) Y2 receptor antagonist with an IC50 value of 19 nM. |
| Targets&IC50 | NPYY2 receptor:19 nM |
| In vitro | SF-11 is a selective brain-permeable NPY Y2 receptor antagonist with IC50 value of 190 nM. A systematic study of the SAR of the hit molecule SF-11 can identify a selective and highly effective small molecule NPY Y2 receptor antagonist CYM 9484 . CYM 9484 is ten times more effective than the hit molecule SF-11. CYM 9484 is prepared by coupling α, α-diphenylpiperidino-4-methanol with various aryl isothiocyanates. |
| Molecular Weight | 509.68 |
| Formula | C27H31N3O3S2 |
| Cas No. | 1383478-94-1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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