Cletoquine oxalate

Cletoquine oxalate (Desethylhydroxychloroquine oxalate) is a major active metabolite of Hydroxychloroquine, with antiviral efficacy against the chikungunya virus (CHIKV), antimalarial effects, and potential for treating autoimmune diseases.

Catalog No. T10835LCas No. 14142-64-4

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Cletoquine oxalate

Catalog No. T10835LCas No. 14142-64-4

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Pack Size	Price	Availability
5 mg	$594	1-2 weeks
25 mg	$1,520	1-2 weeks
50 mg	$1,980	1-2 weeks
100 mg	$2,500	1-2 weeks

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Product Introduction

Bioactivity

Description	Cletoquine oxalate (Desethylhydroxychloroquine oxalate) is a major active metabolite of Hydroxychloroquine, with antiviral efficacy against the chikungunya virus (CHIKV), antimalarial effects, and potential for treating autoimmune diseases.
In vivo	Hydroxychloroquine (5 mg/kg intravenously) is administered to BALB/c mice to determine the concentration of Cletoquine in blood and tissues. The tissue-to-blood concentration ratio (Kp) is ≥1, indicating tissue accumulation of Cletoquine. The Cletoquine Kp ratios in descending order are liver (114.3) > kidney (24.4) > spleen (19.3) > lungs (16.5) > heart (5.5) [3].
Alias	Desethylhydroxychloroquine oxalate

Chemical Properties

Molecular Weight	397.85
Formula	C₁₈H₂₄ClN₃O₅
Cas No.	14142-64-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Keywords

Cletoquine OxalateDesethylhydroxychloroquine OxalateCletoquine oxalate