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Cletoquine

Catalog No. T10835Cas No. 4298-15-1
Alias Desethylhydroxychloroquine

Cletoquine is a major active metabolite of Hydroxychloroquine. Cletoquine has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune disease treatment.

Cletoquine

Cletoquine

Purity: 97.26%
Catalog No. T10835Alias DesethylhydroxychloroquineCas No. 4298-15-1
Cletoquine is a major active metabolite of Hydroxychloroquine. Cletoquine has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune disease treatment.
Pack SizePriceAvailabilityQuantity
1 mg$291In Stock
5 mg$715In Stock
10 mg$987In Stock
25 mg$1,480In Stock
50 mg$1,980In Stock
1 mL x 10 mM (in DMSO)$688In Stock
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Purity:97.26%
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Product Introduction

Bioactivity
Description
Cletoquine is a major active metabolite of Hydroxychloroquine. Cletoquine has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune disease treatment.
In vivo
Hydroxychloroquine is administered intravenously at a dosage of 5 mg/kg to BALB/c mice to assess the Cletoquine levels in blood and tissues. A tissue to blood concentration ratio (Kp) of ≥1 signifies Cletoquine's accumulation in tissues. The observed descending order of the Cletoquine Kp ratios across various tissues is liver (114.3), kidney (24.4), spleen (19.3), lungs (16.5), and heart (5.5).
AliasDesethylhydroxychloroquine
Chemical Properties
Molecular Weight307.82
FormulaC16H22ClN3O
Cas No.4298-15-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 55 mg/mL (178.68 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.2487 mL16.2433 mL32.4865 mL162.4326 mL
5 mM0.6497 mL3.2487 mL6.4973 mL32.4865 mL
10 mM0.3249 mL1.6243 mL3.2487 mL16.2433 mL
20 mM0.1624 mL0.8122 mL1.6243 mL8.1216 mL
50 mM0.0650 mL0.3249 mL0.6497 mL3.2487 mL
100 mM0.0325 mL0.1624 mL0.3249 mL1.6243 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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