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Pack Size | Price | Availability | Quantity |
---|---|---|---|
500 mg | $58 | In Stock | |
1 g | $88 | In Stock | |
1 mL x 10 mM (in DMSO) | $30 | In Stock |
Description | Congo Red (Direct Red 28) is an azo dye. It binding been used as a diagnostic test for the presence of amyloid in tissue sections. |
In vitro | Congo Red histochemical stain may serve as a tool to investigate if aggregates in mutant cells have misfolded β-pleated sheet secondary structures [1]. Congo Red dye specifically binds to crossed β-pleated sheet structures. While wild-type HSPB1 maintains protein homeostasis by binding proteins in non-native conformations and preventing aggregation, the T139M mutant fails in this function, resulting in the accumulation of misfolded proteins targeted by Congo Red for intercalation between the β-pleated sheet structures. |
Alias | Direct Red 28 |
Molecular Weight | 696.66 |
Formula | C32H22N6Na2O6S2 |
Cas No. | 573-58-0 |
Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (143.54 mM), Sonication is recommended. H2O: 4.16 mg/mL (5.97 mM), Sonication and heating are recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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