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Degarelix

Catalog No. T10988 CAS 214766-78-6

Purity 98.00% Datasheet

Degarelix is a competitive and reversible gonadotropin-releasing hormone receptor (GnRHR) antagonist.

Degarelix, CAS 214766-78-6

Pack Size	Availability	Price/USD
2 mg	3-7 days	102.00
5 mg	3-7 days	167.00
10 mg	3-7 days	275.00
50 mg	3-7 days	923.00
100 mg	3-7 days	1733.00

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Purity 98.00%

Datasheet MSDS

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Degarelix is a competitive and reversible gonadotropin-releasing hormone receptor (GnRHR) antagonist.
Targets&IC50	GnRHR,
In vitro	Degarelix directly acts on the pituitary receptors to luteinizing hormone-releasing hormone (LHRH), preventing the effect of endogenous LHRH. The use of degarelix eliminates the undesirable surge of initial gonadotropin and testosterone levels produced by LHRH agonists. With the exception of PC-3 cells, Degarelix treatment reduces the cell viability of all prostate cell lines (WPE1-NA22, WPMY-1, BPH-1 cells, VCaP cells). GnRH antagonist degarelix has a direct effect on the growth of prostate cells through apoptosis.

Molecular Weight	1632.26
Formula	C82H103ClN18O16
CAS No.	214766-78-6

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

H2O: 25 mg/mL (15.32 mM), Need ultrasonic

DMSO: 10 mg/mL (6.13 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Rick FG, et al. An update on the use of degarelix in the treatment of advanced hormone-dependent prostate cancer. Onco Targets Ther. 2013 Apr 16;6:391-402. 2. Sakai M, et al. In search of the molecular mechanisms mediating the inhibitory effect of the GnRH antagonistdegarelix on human prostate cell growth. PLoS One. 2015 Mar 26;10(3):e0120670. 3. Broqua P, et al. Pharmacological profile of a new, potent, and long-acting gonadotropin-releasing hormoneantagonist: degarelix. J Pharmacol Exp Ther. 2002 Apr;301(1):95-102. 4. Sonesson A, et al. Metabolite profiles of degarelix, a new gonadotropin-releasing hormone receptor antagonist, in rat, dog, and monkey. Drug Metab Dispos. 2011 Oct;39(10):1895-903.

Related Products

Related compounds with same targets

Degarelix Danazol Relugolix Goserelin acetate Leuprorelin Leuprolide Acetate Elagolix sodium Cetrorelix

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Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.

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