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Cetrorelix Acetate

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Purity:97.96%

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COA MS HPLC

Cetrorelix Acetate

Catalog No. T5520Cas No. 145672-81-7

Cetrorelix Acetate is gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC50 of 1.21 nM.

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Pack Size	Price	Availability
1 mg	$52	In Stock
2 mg	$68	In Stock
5 mg	$96	In Stock
10 mg	$162	In Stock
25 mg	$338	In Stock
50 mg	$557	In Stock
100 mg	$792	In Stock
1 mL x 10 mM (in DMSO)	$268	In Stock

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Product Introduction

Bioactivity

Description	Cetrorelix Acetate is gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC50 of 1.21 nM.
In vitro	GnRH-I antagonist Cetrorelix inhibited growth of ES-2 cell line only at 1000 ng/ml.?The incubation of ES-2 ovarian cancer cells in vitro with an GnRH-I antibody inhibited cell proliferation in a time and concentration-dependent manner.?GnRH-I may function as an autocrine growth factor in this ovarian cancer cell line [1].
In vivo	Cetrorelix inhibits the activation of hGnRHR and a downstream luciferase reporter gene in murine LTK- cells by the GnRHR agonist [D-Trp6]GnRH (IC50 = 1.2 nM). In vivo, cetrorelix (60 μg per day) reduces tumor volume to 35% of control and decreases serum luteinizing hormone levels by 50% in a human epithelial ovarian cancer mouse xenograft model[2].
Alias	Cetrorelix

Chemical Properties

Molecular Weight	1491.11
Formula	C70H92ClN17O14.C2H4O2
Cas No.	145672-81-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (33.53 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.6706 mL	3.3532 mL	6.7064 mL	33.5321 mL
5 mM	0.1341 mL	0.6706 mL	1.3413 mL	6.7064 mL
10 mM	0.0671 mL	0.3353 mL	0.6706 mL	3.3532 mL
20 mM	0.0335 mL	0.1677 mL	0.3353 mL	1.6766 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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