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Cetrorelix Acetate
🥰Excellent
Catalog No. T5520Cas No. 145672-81-7
Cetrorelix Acetate is gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC50 of 1.21 nM.
Cetrorelix Acetate
🥰Excellent
Purity: 97.96%
Catalog No. T5520Cas No. 145672-81-7
Cetrorelix Acetate is gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC50 of 1.21 nM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $40 | In Stock | |
| 5 mg | $77 | In Stock | |
| 10 mg | $123 | In Stock | |
| 25 mg | $263 | In Stock | |
| 50 mg | $423 | In Stock | |
| 100 mg | $662 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $189 | In Stock |
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Purity:97.96%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Cetrorelix Acetate is gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC50 of 1.21 nM. |
| Targets&IC50 | GnRH:1.21 nM |
| In vitro | GnRH-I antagonist Cetrorelix inhibited growth of ES-2 cell line only at 1000 ng/ml.?The incubation of ES-2 ovarian cancer cells in vitro with an GnRH-I antibody inhibited cell proliferation in a time and concentration-dependent manner.?GnRH-I may function as an autocrine growth factor in this ovarian cancer cell line [1]. |
| In vivo | Cetrorelix inhibits the activation of hGnRHR and a downstream luciferase reporter gene in murine LTK- cells by the GnRHR agonist [D-Trp6]GnRH (IC50 = 1.2 nM). In vivo, cetrorelix (60 μg per day) reduces tumor volume to 35% of control and decreases serum luteinizing hormone levels by 50% in a human epithelial ovarian cancer mouse xenograft model[2]. |
| Molecular Weight | 1491.11 |
| Formula | C70H92ClN17O14.xC2H4O2 |
| Cas No. | 145672-81-7 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (33.53 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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