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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $916 | 8-10 weeks | |
50 mg | $1,190 | 8-10 weeks | |
100 mg | $1,820 | 8-10 weeks |
Description | Dibutyryl-cGMP sodium (Bt2cGMP sodium) is a cell-permeable cGMP analog that preferentially activates cGMP-dependent protein kinase (PKG). It inhibits [3H]-arachidonic acid release in human platelets stimulated by gamma thrombin and can induce peripheral analgesia by activating ATP-sensitive K+ channels. |
In vitro | Dibutyryl-cGMP can induce the process of prolongation and branching of astrocytes, which is caused by the rapid, reversible and concentration-dependent redistribution of glial fibrillary acidic protein (GFAP) and actin filaments, while the protein level No significant changes. When the cells were incubated with succinyl-cGMP (100 μM), the formation of stress fibers was prevented, and the cells obtained a star-like morphology in cerebellar astrocytes. In cells treated with dibutyryl-cGMP (100 μM, 2 h), the particle fraction contained almost no RhoA protein. Dibutyryl-cGMP prevents RhoA-membrane binding. Using the scratch model, the size of the wound in cells treated with succinyl-cGMP after the wound was significantly reduced, indicating that dbcGMP accelerated the wound closure. |
In vivo | Dibutyryl-cGMP (50-200 μg/paw; subcutaneous injection; male Wistar rats) treatment antagonizes the hyperalgesic effect of PGE2 in a dose-dependent manner. The maximum analgesic effect of DbcGMP was 1 h after the administration and continued for more than 2 h. |
Alias | Bt2cGMP sodium |
Molecular Weight | 508.38 |
Formula | C18H24N5NaO9P |
Cas No. | 51116-00-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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