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Dimethyl-SGD-1882

Dimethyl-SGD-1882
Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly efficient DNA alkylating agent used as an antibody-drug conjugate (ADC) cytotoxin, inhibiting DNA replication.
Catalog No. T11046Cas No. 3026416-27-0
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Dimethyl-SGD-1882

Catalog No. T11046Cas No. 3026416-27-0
Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly efficient DNA alkylating agent used as an antibody-drug conjugate (ADC) cytotoxin, inhibiting DNA replication.
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Product Introduction

Bioactivity
Description
Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly efficient DNA alkylating agent used as an antibody-drug conjugate (ADC) cytotoxin, inhibiting DNA replication.
In vitro
The unique structure of Pyrrolobenzodiazepine (PBD) dimer contains two alkylated imines. In addition to monoalkylated adducts, it can also form inter-chain or intra-chain DNA cross-links, therefore Compared with PBD, it has greater DNA stability. Due to the possibility of other types of DNA adducts and higher adduct stability, C8-linked PBD dimers usually have significantly higher cytotoxicity, antitumor activity, and antibacterial activity than PBD monomers And one of the reagents, SJG-136, has entered clinical trials for stage II ovarian cancer and leukemia. In addition, because the related PBD dimer has significant cytotoxicity, it is currently being used as a payload of antibody-drug conjugates (ADC).
AliasDimethyl-PBD dimer
Chemical Properties
Molecular Weight753.84
FormulaC44H43N5O7
Cas No.3026416-27-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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