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EPZ020411

Catalog No. T4314Cas No. 1700663-41-7
Alias EPZ020411 2HCl

EPZ020411 is a specific and effective inhibitor of PRMT6 (IC50=10 nM).

EPZ020411

EPZ020411

Catalog No. T4314Alias EPZ020411 2HClCas No. 1700663-41-7
EPZ020411 is a specific and effective inhibitor of PRMT6 (IC50=10 nM).
Pack SizePriceAvailabilityQuantity
2 mg$1375 days
5 mg$2357-10 days
10 mg$3927-10 days
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Product Introduction

Bioactivity
Description
EPZ020411 is a specific and effective inhibitor of PRMT6 (IC50=10 nM).
Targets&IC50
PRMT6:10 nM
In vitro
In PRMT6-overexpressing cells, EPZ020411 does-dependently inhibits H3R2 methylation.
In vivo
in vivo: EPZ020411 shows good bioavailability following subcutaneous (SC) dosing in rats making it a suitable tool for in vivo studies.
AliasEPZ020411 2HCl
Chemical Properties
Molecular Weight442.6
FormulaC25H38N4O3
Cas No.1700663-41-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 10 mM
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2594 mL11.2969 mL22.5938 mL112.9688 mL
5 mM0.4519 mL2.2594 mL4.5188 mL22.5938 mL
10 mM0.2259 mL1.1297 mL2.2594 mL11.2969 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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