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Ensitrelvir fumarate

Name: Ensitrelvir fumarate
Brand: TargetMol
SKU: T40358
Rating: 4.5 (1 reviews)

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Catalog No. T40358Cas No. 2757470-18-9

Alias S-217622 fumarate

Ensitrelvir (S-217622) fumarate is a novel orally active inhibitor targeting the SARS-CoV-2 3CL protease (IC50 = 13 nM), demonstrating non-covalent and non-peptidic characteristics. This compound represents a pioneering advancement in the development of effective antiviral agents against the SARS-CoV-2 virus.

Ensitrelvir fumarate

😃Good

Catalog No. T40358Alias S-217622 fumarateCas No. 2757470-18-9

Pack Size	Price	Availability	Quantity
2 mg	50 €	5 days

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Product Introduction

Bioactivity

Description	Ensitrelvir (S-217622) fumarate is a novel orally active inhibitor targeting the SARS-CoV-2 3CL protease (IC50 = 13 nM), demonstrating non-covalent and non-peptidic characteristics. This compound represents a pioneering advancement in the development of effective antiviral agents against the SARS-CoV-2 virus.
In vitro	In a cytopathic effect (cpe)-inhibition assay on VeroE6/TMPRSS2 cells infected with SARS-CoV-2, Ensitrelvir fumarate demonstrated EC50 values of approximately 0.4 μM for the wild-type virus and the Alpha, Beta, Gamma, and Delta variants, and EC50 values of 0.21 μM and 1.4 μM for SARS-CoV and MERS-CoV, respectively[1].
In vivo	Ensitrelvir fumarate effectively reduces SARS-CoV-2 replication within the lungs of mice in a dose-dependent manner[2].
Alias	S-217622 fumarate

Chemical Properties

Molecular Weight	647.96
Formula	C₂₆H₂₁ClF₃N₉O₆
Cas No.	2757470-18-9
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Ensitrelvir FumarateEnsitrelvir fumarateS 217622 FumarateS217622 FumarateS-217622 Fumarate