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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 6-8 weeks | |
50 mg | $1,980 | 6-8 weeks | |
100 mg | $2,500 | 6-8 weeks |
Description | FK-448 Free base is a potent and specific chymotrypsin inhibitor, with an IC50 of 720 nM. |
Targets&IC50 | Chymotrypsin:720 nM |
In vitro | FK-448 Free base slightly inhibits esterolysis of Trypsin and Thrombin, with IC50s of 780 and 35 μM, respectively, but shows no effects on esterolysis of plasmin, plasma kallikrein or pancreas kallikrein, with IC50s of all >1 mM. FK-448 moderately inhibits hydrolytic activities of cathepsin G with an IC50 of 15 μM. FK-448 Free base is an effective and specific inhibitor of chymotrypsin, with an IC50 of 720 nM. |
In vivo | FK-448, administered orally (p.o.) at a dose of 20 mg/kg, not only reduces the blood glucose level but also elevates the plasma Insulin Release Inhibitor (IRI) level in dogs. Meanwhile, when delivered intraperitoneally (i.p.) at the same dosage, FK-448 leads to a decreased blood glucose level and prevents the breakdown of insulin by pancreatic enzymes in rats. |
Molecular Weight | 406.52 |
Formula | C25H30N2O3 |
Cas No. | 85858-76-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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