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FK-448 Free base

Catalog No. T11290 CAS 85858-76-0

FK-448 Free base is an effective and specific inhibitor of chymotrypsin, with an IC50 of 720 nM.

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FK-448 Free base, CAS 85858-76-0

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	FK-448 Free base is an effective and specific inhibitor of chymotrypsin, with an IC50 of 720 nM.
Targets&IC50	Chymotrypsin:720 nM
In vitro	FK-448 Free base slightly inhibits esterolysis of Trypsin and Thrombin, with IC50s of 780 and 35 μM, respectively, but shows no effects on esterolysis of plasmin, plasma kallikrein or pancreas kallikrein, with IC50s of all >1 mM. FK-448 moderately inhibits hydrolytic activities of cathepsin G with an IC50 of 15 μM. FK-448 Free base is an effective and specific inhibitor of chymotrypsin, with an IC50 of 720 nM.
In vivo	FK-448, administered orally (p.o.) at a dose of 20 mg/kg, not only reduces the blood glucose level but also elevates the plasma Insulin Release Inhibitor (IRI) level in dogs. Meanwhile, when delivered intraperitoneally (i.p.) at the same dosage, FK-448 leads to a decreased blood glucose level and prevents the breakdown of insulin by pancreatic enzymes in rats.

Molecular Weight	406.52
Formula	C25H30N2O3
CAS No.	85858-76-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Fujii S, et al. New synthetic inhibitors of chymotrypsin. J Biochem. 1984 Feb;95(2):319-22. 2. Fujii S, et al. Promoting effect of the new chymotrypsin inhibitor FK-448 on the intestinal absorption of insulin in rats and dogs. J Pharm Pharmacol. 1985 Aug;37(8):545-9.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

FK-448 Free base 85858-76-0 Others FK 448 Free base FK 448 FK448 Free base FK448 FK-448 inhibitor inhibit

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