Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

FK-448 Free base

Catalog No. T11290Cas No. 85858-76-0

FK-448 Free base is a potent and specific chymotrypsin inhibitor, with an IC50 of 720 nM.

FK-448 Free base

FK-448 Free base

Catalog No. T11290Cas No. 85858-76-0
FK-448 Free base is a potent and specific chymotrypsin inhibitor, with an IC50 of 720 nM.
Pack SizePriceAvailabilityQuantity
25 mg$1,5206-8 weeks
50 mg$1,9806-8 weeks
100 mg$2,5006-8 weeks
Bulk & Custom
Add to Cart
Questions
View More
Contact us for more batch information
Resource Download
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
FK-448 Free base is a potent and specific chymotrypsin inhibitor, with an IC50 of 720 nM.
Targets&IC50
Chymotrypsin:720 nM
In vitro
FK-448 Free base slightly inhibits esterolysis of Trypsin and Thrombin, with IC50s of 780 and 35 μM, respectively, but shows no effects on esterolysis of plasmin, plasma kallikrein or pancreas kallikrein, with IC50s of all >1 mM. FK-448 moderately inhibits hydrolytic activities of cathepsin G with an IC50 of 15 μM. FK-448 Free base is an effective and specific inhibitor of chymotrypsin, with an IC50 of 720 nM.
In vivo
FK-448, administered orally (p.o.) at a dose of 20 mg/kg, not only reduces the blood glucose level but also elevates the plasma Insulin Release Inhibitor (IRI) level in dogs. Meanwhile, when delivered intraperitoneally (i.p.) at the same dosage, FK-448 leads to a decreased blood glucose level and prevents the breakdown of insulin by pancreatic enzymes in rats.
Chemical Properties
Molecular Weight406.52
FormulaC25H30N2O3
Cas No.85858-76-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy FK-448 Free base | purchase FK-448 Free base | FK-448 Free base cost | order FK-448 Free base | FK-448 Free base chemical structure | FK-448 Free base in vivo | FK-448 Free base in vitro | FK-448 Free base formula | FK-448 Free base molecular weight