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FMK-MEA

Name: FMK-MEA
Brand: TargetMol
SKU: T11310
Rating: 4.5 (1 reviews)

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Catalog No. T11310Cas No. 1414811-15-6

FMK-MEA is a potent and selective inhibitor of p90 Ribosomal S6 Kinase (RSK).

FMK-MEA

😃Good

Catalog No. T11310Cas No. 1414811-15-6

FMK-MEA is a potent and selective inhibitor of p90 Ribosomal S6 Kinase (RSK).

Pack Size	Price	Availability
25 mg	$2,270	10-14 weeks
50 mg	$2,980	10-14 weeks
100 mg	$4,000	10-14 weeks

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Product Introduction

Bioactivity

Description	FMK-MEA is a potent and selective inhibitor of p90 Ribosomal S6 Kinase (RSK).
In vitro	Treatment with FMK-MEA, a water-soluble derivative of fmk, effectively inhibits RSK2 kinase activity across a range of highly invasive human cancer cell lines, including 212LN, M4e, A549, and SKBR3. This RSK-specific inhibitor significantly reduces RSK2 activity in A549 cells, as evidenced by decreased phosphorylation levels of Ser-386, thereby diminishing their invasive capabilities.
In vivo	FMK-MEA administration at a dosage of 80 mg/kg/day via intraperitoneal injection over 16 days in xenograft nude mice with highly metastatic M4e cells does not alter the size or proliferation rate of the primary tumor. However, it significantly reduces lymph node (LN) metastasis.

Chemical Properties

Molecular Weight	399.46
Formula	C₂₁H₂₆FN₅O₂
Cas No.	1414811-15-6
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

p90 RSKFMK-MEAFMKMEAFMK MEA