Powder: -20°C for 3 years | In solvent: -80°C for 1 year
FMK-MEA is a potent and selective p90 Ribosomal S6 Kinase (RSK) inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 2,270.00 | |
50 mg | 10-14 weeks | $ 2,980.00 | |
100 mg | 10-14 weeks | $ 4,000.00 |
Description | FMK-MEA is a potent and selective p90 Ribosomal S6 Kinase (RSK) inhibitor. |
In vitro | Treatment with FMK-MEA, a water-soluble derivative of fmk, effectively inhibits RSK2 kinase activity across a range of highly invasive human cancer cell lines, including 212LN, M4e, A549, and SKBR3. This RSK-specific inhibitor significantly reduces RSK2 activity in A549 cells, as evidenced by decreased phosphorylation levels of Ser-386, thereby diminishing their invasive capabilities. |
In vivo | FMK-MEA administration at a dosage of 80 mg/kg/day via intraperitoneal injection over 16 days in xenograft nude mice with highly metastatic M4e cells does not alter the size or proliferation rate of the primary tumor. However, it significantly reduces lymph node (LN) metastasis. |
Molecular Weight | 399.46 |
Formula | C21H26FN5O2 |
CAS No. | 1414811-15-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
FMK-MEA 1414811-15-6 Others FMKMEA FMK MEA inhibitor inhibit