Shopping Cart
- Remove All
Your shopping cart is currently empty
FMK-MEA
Catalog No. T11310Cas No. 1414811-15-6
FMK-MEA is a potent and selective inhibitor of p90 Ribosomal S6 Kinase (RSK).
FMK-MEA
Catalog No. T11310Cas No. 1414811-15-6
FMK-MEA is a potent and selective inhibitor of p90 Ribosomal S6 Kinase (RSK).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $2,270 | 10-14 weeks | |
| 50 mg | $2,980 | 10-14 weeks | |
| 100 mg | $4,000 | 10-14 weeks |
Bulk & Custom
Add to Cart
Questions
View MoreContact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | FMK-MEA is a potent and selective inhibitor of p90 Ribosomal S6 Kinase (RSK). |
| In vitro | Treatment with FMK-MEA, a water-soluble derivative of fmk, effectively inhibits RSK2 kinase activity across a range of highly invasive human cancer cell lines, including 212LN, M4e, A549, and SKBR3. This RSK-specific inhibitor significantly reduces RSK2 activity in A549 cells, as evidenced by decreased phosphorylation levels of Ser-386, thereby diminishing their invasive capabilities. |
| In vivo | FMK-MEA administration at a dosage of 80 mg/kg/day via intraperitoneal injection over 16 days in xenograft nude mice with highly metastatic M4e cells does not alter the size or proliferation rate of the primary tumor. However, it significantly reduces lymph node (LN) metastasis. |
| Molecular Weight | 399.46 |
| Formula | C21H26FN5O2 |
| Cas No. | 1414811-15-6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy FMK-MEA | purchase FMK-MEA | FMK-MEA cost | order FMK-MEA | FMK-MEA chemical structure | FMK-MEA in vivo | FMK-MEA in vitro | FMK-MEA formula | FMK-MEA molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.