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FRG8701

FRG8701
FRG8701 is a new Histamine H2-receptor antagonist with an IC50 of ranging from 0.25 to 0.43 μM.
Catalog No. T11324Cas No. 108498-50-6

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FRG8701

Catalog No. T11324Cas No. 108498-50-6

FRG8701 is a new Histamine H2-receptor antagonist with an IC50 of ranging from 0.25 to 0.43 μM.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
25 mg$1,5206-8 weeks
50 mg$1,9806-8 weeks
100 mg$2,5006-8 weeks
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Product Introduction

Bioactivity
Description
FRG8701 is a new Histamine H2-receptor antagonist with an IC50 of ranging from 0.25 to 0.43 μM.
Targets&IC50
H2 receptor:0.25 to 0.43 μM
In vitro
The inhibitory potency of FRG8701 is almost the same as that of famotidine and approximately 33 times greater than that of cimetidine.Positive chronotropic response to histamine at 10-5 M is dose dependently inhibited by FRG8701 (FRG-8701) famotidine or cimetidine;?and the IC50 values of FRG8701, famotidine and cimetidine are 3.3, 3.0 and 108.6 (×10-7M), respectively.
In vivo
FRG8701 effectively inhibits the formation of gastric lesions induced by various necrotizing agents, demonstrating its protective effects on the gastrointestinal tract. Oral administration of FRG8701 produces a dose-dependent reduction in the development of gastric lesions caused by stress, indomethacin, and the formation of duodenal ulcers due to mepirizole, with ED50 values ranging from 1.1 to 9.4 mg/kg for gastric lesions and 1.7 to 6.9 mg/kg for each ulcer model. Additionally, in pylorus-ligated rats, intraduodenal delivery of FRG8701 dose-dependently decreases total acid output. Furthermore, FRG8701, whether administered orally or intraperitoneally at doses of 10 or 30 mg/kg, significantly prevents gastric mucosal lesions induced by 0.4 N HCl+50% ethanol, underscoring its potential as a protective agent against gastrointestinal damage.
Chemical Properties
Molecular Weight418.55
FormulaC22H30N2O4S
Cas No.108498-50-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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