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GABAA receptor agent 5

Name: GABAA receptor agent 5
Brand: TargetMol
SKU: T61668
Rating: 4.5 (1 reviews)

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Catalog No. T61668Cas No. 1808389-92-5

GABAA Receptor Agent 5 (compound 018) serves as a potent γ-GABAAR antagonist, possessing a Ki of 0.020 μM. This compound exhibits γ-GABAAR antagonist properties, yet it demonstrates low cellular membrane permeability [1].

GABAA receptor agent 5

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Catalog No. T61668Cas No. 1808389-92-5

Pack Size	Price	Availability
25 mg	1.444 €	6-8 weeks
50 mg	1.881 €	6-8 weeks
100 mg	2.375 €	6-8 weeks

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Product Introduction

Bioactivity

Description	GABAA Receptor Agent 5 (compound 018) serves as a potent γ-GABAAR antagonist, possessing a Ki of 0.020 μM. This compound exhibits γ-GABAAR antagonist properties, yet it demonstrates low cellular membrane permeability [1].
In vitro	Compound 018, a GABAA receptor agent, exhibits antagonist activity, demonstrated by its IC50 values. These are 0.24 μM for α1β2δ, 0.088 μM for α4β1δ, 0.068 μM for α4β2δ, 0.33 μM for α6β2δ, 0.79 μM for α1β2γ2, 0.32 μM for α2β2γ2, 0.079 μM for α3β2γ2, and 0.051 μM for α5β2γ2 subtypes, respectively [1].

Chemical Properties

Molecular Weight	383.51
Formula	C₂₁H₂₅N₃O₂S
Cas No.	1808389-92-5

Storage & Solubility Information

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc