GLP-1 (9-36) amide

GLP-1 (9-36) amide is an antagonist at the human GLP-1 receptor. GLP-1 (9-36) amide potently inhibits hepatic glucose production (HGP) and is a weak insulinotropic agent.

Catalog No. TP2252Cas No. 161748-29-4

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Purity:97%

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GLP-1 (9-36) amide

Catalog No. TP2252Cas No. 161748-29-4

GLP-1 (9-36) amide is an antagonist at the human GLP-1 receptor. GLP-1 (9-36) amide potently inhibits hepatic glucose production (HGP) and is a weak insulinotropic agent.

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Pack Size	Price	Availability
1 mg	$81	In Stock
5 mg	$255	In Stock
10 mg	$378	In Stock
25 mg	$626	In Stock
50 mg	$883	In Stock
100 mg	$1,190	In Stock

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Product Introduction

Bioactivity

Description

antagonist at the human GLP-1 receptor

In vivo

After subcutaneous (s.c.) administration of GLP-1 to dogs the plasma immunoreactivity of GLP-1 measured by two different radioimmunoassays (RIAs) were higher than that measured by a sandwich enzyme-linked immunosorbent assay (ELISA). This discrepancy was due to the formation of the metabolites GLP-1-(9-36) amide, GLP-1-(7-35) and GLP-1-(7-34). Receptor binding studies using baby hamster kidney cells expressing the human pancreatic GLP-1 receptor showed that the affinity of GLP-1-(9-36) amide was 0.95% of the affinity of GLP-1-(7-36) amide. Furthermore, GLP-1-(9-36) amide was shown to be an antagonist to adenylyl cyclase activity. GLP-1-(9-36) amide was shown to be present in vivo in amounts up to 10-fold that of GLP-1-(7-36) amide[2].

Chemical Properties

Molecular Weight	3089.41
Formula	C₁₄₀H₂₁₄N₃₆O₄₃
Cas No.	161748-29-4

Storage & Solubility Information

Storage	store at low temperature,keep away from moisture
Solubility Information	0.025% acetic acid: 2 mg/ml

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