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GYKI 53655 hydrochloride

Catalog No. T15456 CAS 143692-48-2

Synonyms: GYKI53655 hydrochloride, LY300168 hydrochloride

GYKI 53655 hydrochloride (LY300168 hydrochloride) is an antagonist of AMPA and is used in the study of neurological disorders.

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GYKI 53655 hydrochloride Chemical Structure

GYKI 53655 hydrochloride, CAS 143692-48-2

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Purity: 98.02%

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Storage & Solubility Information

Description	GYKI 53655 hydrochloride (LY300168 hydrochloride) is an antagonist of AMPA and is used in the study of neurological disorders.
Targets&IC50	mGluR4:5 μM, mGluR1:6 μM
In vitro	GYKI 53655 hydrochloride inhibited AMPA (10 μM)-mediated responses in recombinant human GluR1 receptors expressed in HEK293 cells and recombinant human GluR4 receptors expressed in HEK293 cells with approximate IC50 values of 6 μM and 5 μM, respectively.[1].
In vivo	GYKI 53655 hydrochloride (2-8 mg/kg) can dose-dependently inhibit or completely abolish AMPA responses in vivo[3].

Synonyms	GYKI53655 hydrochloride, LY300168 hydrochloride
Molecular Weight	388.85
Formula	C19H21ClN4O3
CAS No.	143692-48-2

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 120 mg/mL (308.60 mM), Sonification is recommended.

H2O: 2 mg/mL (5.14 mM), Sonification is recommended.

References and Literature

1. Bleakman D, et al. Activity of 2,3-benzodiazepines at native rat and recombinant human glutamate receptors in vitro: stereospecificity and selectivity profiles. Neuropharmacology. 1996;35(12):1689-702. 2. Chizh BA, et al. A comparison of intravenous NBQX and GYKI 53655 as AMPA antagonists in the rat spinal cord. Br J Pharmacol. 1994 Jul;112(3):843-6. 3. Szabados T, et al. Comparison of anticonvulsive and acute neuroprotective activity of three 2,3-benzodiazepine compounds, GYKI 52466, GYKI 53405, and GYKI 53655. Brain Res Bull. 2001 Jun;55(3):387-91.

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Keywords

GYKI 53655 hydrochloride 143692-48-2 Neuroscience GluR GYKI53655 hydrochloride LY300168 hydrochloride GYKI-53655 Hydrochloride inhibitor inhibit

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