Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H3R-IN-1 Hydrochloride is an inverse agonist of histamine receptor 3( H3R ) .
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 1,110.00 | |
50 mg | 10-14 weeks | $ 1,450.00 | |
100 mg | 10-14 weeks | $ 2,280.00 |
Description | H3R-IN-1 Hydrochloride is an inverse agonist of histamine receptor 3( H3R ) . |
In vitro | Treatment with H3R-IN-1, which is a H3R inverse agonist, promotes oligodendrocyte precursor cell (OPC) differentiation in a dose-dependent manner, at EC 50 =25 nM. Western blot shows a significant increase in expression levels of two markers of mature oligodendrocytes, myelin-associated glycoprotein (MAG) and myeline basic protein (MBP) in differentiating oligodendrocytes after treatment with H3R-IN-1, which reveals that treatment with H3R-IN-1 drives more OPCs to differentiate. H3R-IN-1 increases the Forskolin-stimulated cAMP level in the primary oligodendrocyte precursor cells in a dose-dependent manner [1]. |
In vivo | The ability of H3R-IN-1 to enhance remyelination in vivo is determined using the Cuprizone/Rapamycin-induced demyelination model. Mice are treated with Cuprizone diet combined with intraperitoneal injections of Rapamycin for 5 weeks followed by 9 days of compound administration. Cuprizone diet plus intraperitoneal injections of Rapamycin induced severe demyelination in both corpus callosum and cortex and treatment with H3R-IN-1 (30 mg/kg, 9 days) significantly increases density of myelin specific Black-gold II staining in the lesion of corpus callosum and cortex in forebrain, compared to vehicle control group [1]. |
Molecular Weight | 377.87 |
Formula | C19H24ClN3O3 |
CAS No. | 2319790-07-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (66.16 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
H3R-IN-1 Hydrochloride 2319790-07-1 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor H3RIN1 Hydrochloride H3R IN 1 Hydrochloride H-3R-IN-1 Hydrochloride inhibitor inhibit