store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HSR6071 is a novel orally active and potent anti-allergic agent with inhibitory effects on passive cutaneous anaphylaxis. HSR6071 showed anti-asthmatic activity in a rat model of experimental asthma.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 169.00 | |
5 mg | In stock | $ 291.00 | |
10 mg | In stock | $ 465.00 | |
50 mg | 6-8 weeks | $ 1,610.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | HSR6071 is a novel orally active and potent anti-allergic agent with inhibitory effects on passive cutaneous anaphylaxis. HSR6071 showed anti-asthmatic activity in a rat model of experimental asthma. |
In vivo | HSR-6071 (0.01-0.1 mg/kg; i.v.) inhibits experimental asthma induced by IgE antibody in rats in a dose-dependent manner. Additionally, HSR-6071 (0.3, 1.3 mg/kg; i.v.) prevents bronchoconstriction mediated by IgE or IgG antibody in guinea pigs. The compound inhibits cyclic AMP phosphodiesterase activity and induces relaxation of the guinea pig isolated trachea[1].With an IC50 of 0.46 nM, HSR-6071 inhibits IgE-mediated histamine release. Its effectiveness is observed not only through intravenous (i.v.) administration but also through oral (p.o.) administration in IgE-mediated passive cutaneous anaphylaxis (PCA) in rats. The most potent inhibition with HSR-6071 occurs when administered orally 5 minutes before the antigen challenge, indicating rapid absorption through the gastrointestinal tract[1]. |
Molecular Weight | 260.26 |
Formula | C10H12N8O |
CAS No. | 111374-21-1 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 20 mg/mL (76.85 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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HSR6071 111374-21-1 Others HSR 6071 HSR-6071 inhibitor inhibit