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IACS-8779

Catalog No. T11595 CAS 2243079-26-5

IACS-8779 is a potent STING agonist that efficiently stimulates interferon gene activity and exhibits strong systemic antitumor effects.

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IACS-8779, CAS 2243079-26-5

Pack Size	Availability	Price/USD
25 mg	10-14 weeks	$ 3,920.00
50 mg	10-14 weeks	$ 5,180.00
100 mg	10-14 weeks	$ 7,300.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

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Description

IACS-8779 is a potent STING agonist that efficiently stimulates interferon gene activity and exhibits strong systemic antitumor effects.

In vivo

Mice bilaterally implanted with B16-Ova tumors received intra-tumoral injections of IACS-8779 (compound 1a) at a 10 μg dose solely on one flank at intervals of three days, specifically on days 6, 9, and 12 post-implantation. While IACS-8779 demonstrated comparable antitumor efficacy on the treated flank, it elicited superior tumor regression on the untreated, contralateral flank. This indicates a stronger systemic immune response by IACS-8779 than that achieved by benchmark analogs. Furthermore, treatment with IACS-8779 resulted in a higher rate of mice being cured of tumors on both flanks, surpassing the outcomes observed with benchmark treatments.

Molecular Weight	689.55
Formula	C21H25N9O10P2S2
CAS No.	2243079-26-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Ager CR, et al. Discovery of IACS-8803 and IACS-8779, potent agonists of stimulator of interferon genes (STING) with robust systemic antitumor efficacy. Bioorg Med Chem Lett. 2019 Oct 15;29(20):126640.

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Keywords

IACS-8779 2243079-26-5 Others IACS8779 IACS 8779 inhibitor inhibit

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