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INCB 3284 dimesylate

Catalog No. T11647Cas No. 887401-93-6

INCB 3284 dimesylate is a selective and orally bioavailable human CCR2 antagonist, inhibiting monocyte chemoattractant protein-1 binding to hCCR2 (IC50: 3.7 nM). It can be used in the research of acute liver failure.

INCB 3284 dimesylate

INCB 3284 dimesylate

Catalog No. T11647Cas No. 887401-93-6
INCB 3284 dimesylate is a selective and orally bioavailable human CCR2 antagonist, inhibiting monocyte chemoattractant protein-1 binding to hCCR2 (IC50: 3.7 nM). It can be used in the research of acute liver failure.
Pack SizePriceAvailabilityQuantity
1 mg$12835 days
10 mg$38935 days
50 mg$1,77935 days
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Product Introduction

Bioactivity
Description
INCB 3284 dimesylate is a selective and orally bioavailable human CCR2 antagonist, inhibiting monocyte chemoattractant protein-1 binding to hCCR2 (IC50: 3.7 nM). It can be used in the research of acute liver failure.
Targets&IC50
MCP-1-hCCR2:3.7 nM
In vitro
INCB 3284 causes an IC50 of 4.7 nM in antagonism of chemotaxis activity, an IC50 of 84 μM in inhibition of the hERG potassium current. However, INCB 3284 has no effec on CCR1, CCR3, CCR5, CXCR3, and CXCR5, or additional GPCRs at a concentration of 1 μM. Moreover, INCB 3284 potently inhibits CCR2-mediated signaling events such as intracellular calcium mobilization and ERK phosphorylation with IC50 values of 6 and 2.6 nM, respectively.INCB 3284 dimesylate is a pentent, selective and orally bioavailable human CCR2 antagonist, inhibiting monocyte chemoattractant protein-1 binding to hCCR2, with an IC50 of 3.7 nM.?INCB 3284 also causes an IC50 of 4.7 nM in antagonism of chemotaxis activity, an IC50 of 84 μM in inhibition of the hERG potassium current.?However, INCB 3284 has no effec on CCR1, CCR3, CCR5, CXCR3, and CXCR5, or additional GPCRs at a concentration of 1 μM.?Moreover, INCB 3284 potently inhibits CCR2-mediated signaling events such as intracellular calcium mobilization and ERK phosphorylation with IC50 values of 6 and 2.6 nM, respectively.
In vivo
INCB 3284 effectively diminishes the ratio of phosphorylated ERK1/2 (pERK1/2) to total ERK1/2 (tERK1/2), alongside reducing G-protein signaling pathway activity and the production of proinflammatory cytokines in cortex lysates of mice treated with azoxymethane. Additionally, administered at a dosage of 1 mg/kg/day intraperitoneally, it alleviates liver damage and curtails microglia activation in azoxymethane (AOM)-treated mice through the inhibition of CCR2.
Chemical Properties
Molecular Weight712.76
FormulaC28H39F3N4O10S2
Cas No.887401-93-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 83.3 mg/mL (116.87 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.4030 mL7.0150 mL14.0300 mL70.1498 mL
5 mM0.2806 mL1.4030 mL2.8060 mL14.0300 mL
10 mM0.1403 mL0.7015 mL1.4030 mL7.0150 mL
20 mM0.0701 mL0.3507 mL0.7015 mL3.5075 mL
50 mM0.0281 mL0.1403 mL0.2806 mL1.4030 mL
100 mM0.0140 mL0.0701 mL0.1403 mL0.7015 mL

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