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IQ-R
IQ-R is a novel hypoxia-sensitive fluorescent probe composed of an indolequinone unit coupled with a rhodol fluorophore.
Catalog No. T15593Cas No. 1345445-57-9
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IQ-R
Catalog No. T15593Cas No. 1345445-57-9
IQ-R is a novel hypoxia-sensitive fluorescent probe composed of an indolequinone unit coupled with a rhodol fluorophore.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
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Bioactivity
Chemical Properties
| Description | IQ-R is a novel hypoxia-sensitive fluorescent probe composed of an indolequinone unit coupled with a rhodol fluorophore. |
| In vitro | IQ-R is activated and reduced by endogenous reductase preferentially under hypoxic conditions when administered to A549 cells, thereby visualizing hypoxic cancer cells by robust fluorescence. While the fluorescence of rhodol in the IQ-R conjugate is quenched by the function of the intramolecular indolequinone unit, it is restored under hypoxic conditions through the enzymatic one-electron reduction of IQ-R by NADPH: cytochrome P450 reductase to release the nonconjugated free rhodol. IQ-R has good solubility in water and longer wavelength for absorption and emission, which are favorable for cellular bioimaging. |
| Molecular Weight | 576.6 |
| Formula | C34H28N2O7 |
| Cas No. | 1345445-57-9 |
Storage & Solubility Information
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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