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IQ-R

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Catalog No. T15593Cas No. 1345445-57-9

IQ-R is a novel hypoxia-sensitive fluorescent probe composed of an indolequinone unit coupled with a rhodol fluorophore.

IQ-R

IQ-R

😃Good
Catalog No. T15593Cas No. 1345445-57-9
IQ-R is a novel hypoxia-sensitive fluorescent probe composed of an indolequinone unit coupled with a rhodol fluorophore.
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Product Introduction

Bioactivity
Description
IQ-R is a novel hypoxia-sensitive fluorescent probe composed of an indolequinone unit coupled with a rhodol fluorophore.
In vitro
IQ-R is activated and reduced by endogenous reductase preferentially under hypoxic conditions when administered to A549 cells, thereby visualizing hypoxic cancer cells by robust fluorescence. While the fluorescence of rhodol in the IQ-R conjugate is quenched by the function of the intramolecular indolequinone unit, it is restored under hypoxic conditions through the enzymatic one-electron reduction of IQ-R by NADPH: cytochrome P450 reductase to release the nonconjugated free rhodol. IQ-R has good solubility in water and longer wavelength for absorption and emission, which are favorable for cellular bioimaging.
Chemical Properties
Molecular Weight576.6
FormulaC34H28N2O7
Cas No.1345445-57-9
Relative Density.no data available
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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