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IZCZ-3

Catalog No. T11698 CAS 2223019-53-0

IZCZ-3,antitumor activity. is a potent c-MYC transcription inhibitor.

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IZCZ-3, CAS 2223019-53-0

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,230.00
50 mg	6-8 weeks	$ 1,610.00
100 mg	6-8 weeks	$ 2,390.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	IZCZ-3,antitumor activity. is a potent c-MYC transcription inhibitor.
In vitro	IZCZ-3 induces only weak growth inhibition in the BJ fibroblasts (IC50=15.9 μM) and mouse mesangial cells (IC50=15.6 μM), suggesting that IZCZ-3 is more effective against cancer cells than against c-MYC-independent normal cells. IZCZ-3 (0-5 μM; 12 hours) induces an apparent accumulation of cells in the G0/G1 phase in SiHa cells in a dose-dependent manner.IZCZ-3 (2.1 μM-15.9 μM; 24 hours) significantly inhibits SiHa, HeLa, Huh7, and A375 cancer cell proliferation (IC50s of 3.3, 2.1,4.1, and 4.2 μM, respectively).
In vivo	IZCZ-3 inhibits tumor growth in BALB/c nude mice with SiHa human cervical squamous cancer xenograft.

Molecular Weight	715.93
Formula	C46H49N7O
CAS No.	2223019-53-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5 mg/mL (6.98 mM), Sonication and heating to 80℃ are recommended.

References and Literature

1. Hu MH, et al. Discovery of a New Four-Leaf Clover-Like Ligand as a Potent c-MYC Transcription Inhibitor Specifically Targeting the Promoter G-Quadruplex. J Med Chem. 2018 Mar 22;61(6):2447-2459.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

IZCZ-3 2223019-53-0 Others IZCZ3 IZCZ 3 inhibitor inhibit

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