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Iodophenpropit dihydrobromide

Catalog No. T15590 CAS 145196-87-8

Iodophenpropit dihydrobromide is an effective and selective antagonist of the histamine H3 receptor. The binding of [125I]Iodophenpropit is readily reversible, selective, and of high affinity (KD: 0.32 nM).

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Iodophenpropit dihydrobromide Chemical Structure

Iodophenpropit dihydrobromide, CAS 145196-87-8

Pack Size	Availability	Price/USD	Quantity
5 mg	4-5 weeks	$ 296.00
10 mg	4-5 weeks	$ 443.00

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Description	Iodophenpropit dihydrobromide is an effective and selective antagonist of the histamine H3 receptor. The binding of [125I]Iodophenpropit is readily reversible, selective, and of high affinity (KD: 0.32 nM).
Targets&IC50	H3 receptor:0.32 nM (kd)
In vitro	Iodophenpropit suppresses 5-hydroxytryptamine (5-HT) responses (IC50 of 1.57±0.3 μM)[3]. Iodophenpropit is a very potent H3 receptor antagonist and displays only a moderate affinity for the H1 and H2 receptors [2].
In vivo	In rabbits, Iodophenpropit (1 μg/kg; through intramuscular; b.i.d.; for 10 days) displays obviously enhancement of total anti-sheep red blood cells (SRBC)- immunoglobulins (Igs)[4].

Molecular Weight	495.22
Formula	C15H20BrIN4S
CAS No.	145196-87-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Jansen FP, et al. The first radiolabeled histamine H3 receptor antagonist, [ 2. Leurs R, et al. Evaluation of the receptor selectivity of the H3 receptor antagonists, Iodophenpropit and thioperamide: an interaction with the 5-HT3 receptor revealed. Br J Pharmacol. 1995 Oct;116(4):2315-21. 3. Allen MC. Agonist and antagonist effects of histamine H3 receptor ligands on 5-HT3 receptor-mediated ion currents in NG108-15 cells. Eur J Pharmacol. 1998 Nov 20;361(2-3):261-8. 4. Trivendra Tripathi, et al. In vivo immunomodulatory profile of histamine receptors (H1, H2, H3 and H4): a comparative antagonists study. Asian Pac J Trop Med. 2010 Jun;3(6):465-470.

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Keywords

Iodophenpropit dihydrobromide 145196-87-8 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor Iodophenpropit Dihydrobromide Iodophenpropit inhibitor inhibit

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