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Ipatasertib-NH2

Ipatasertib-NH2
Ipatasertib-NH2 (GDC-0068-NH2;RG7440-NH2) is a ligand for the target protein AKT used in PROTAC, binding to lenalidomide, a ligand of ubiquitin E3 ligase cereblon (CRBN), via a ten-hydrocarbon linker to form INY-03-041 for AKT degradation[1].
Catalog No. T18053Cas No. 1001382-14-4
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Ipatasertib-NH2

Catalog No. T18053Cas No. 1001382-14-4
Ipatasertib-NH2 (GDC-0068-NH2;RG7440-NH2) is a ligand for the target protein AKT used in PROTAC, binding to lenalidomide, a ligand of ubiquitin E3 ligase cereblon (CRBN), via a ten-hydrocarbon linker to form INY-03-041 for AKT degradation[1].
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Product Introduction

Bioactivity
Description
Ipatasertib-NH2 (GDC-0068-NH2;RG7440-NH2) is a ligand for the target protein AKT used in PROTAC, binding to lenalidomide, a ligand of ubiquitin E3 ligase cereblon (CRBN), via a ten-hydrocarbon linker to form INY-03-041 for AKT degradation[1].
In vitro
PROTACs, composed of two ligands connected by a linker—one binding to an E3 ubiquitin ligase and the other to the target protein—utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
AliasRG7440-NH2, GDC-0068-NH2
Chemical Properties
Molecular Weight415.92
FormulaC21H26ClN5O2
Cas No.1001382-14-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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