Ipatasertib-NH2

Ipatasertib-NH2 (GDC-0068-NH2;RG7440-NH2) is a ligand for the target protein AKT used in PROTAC, binding to lenalidomide, a ligand of ubiquitin E3 ligase cereblon (CRBN), via a ten-hydrocarbon linker to form INY-03-041 for AKT degradation[1].

Catalog No. T18053Cas No. 1001382-14-4

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Ipatasertib-NH2

Catalog No. T18053Cas No. 1001382-14-4

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Product Introduction

Bioactivity

Description	Ipatasertib-NH2 (GDC-0068-NH2;RG7440-NH2) is a ligand for the target protein AKT used in PROTAC, binding to lenalidomide, a ligand of ubiquitin E3 ligase cereblon (CRBN), via a ten-hydrocarbon linker to form INY-03-041 for AKT degradation[1].
In vitro	PROTACs, composed of two ligands connected by a linker—one binding to an E3 ubiquitin ligase and the other to the target protein—utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Alias	RG7440-NH2, GDC-0068-NH2

Chemical Properties

Molecular Weight	415.92
Formula	C₂₁H₂₆ClN₅O₂
Cas No.	1001382-14-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Keywords

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