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JHU-083
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Catalog No. T15613Cas No. 1998725-11-3
Alias JHU083
JHU-083 is an orally available, blood-brain barrier-crossing, selective glutaminase antagonist that improves cognitive performance and normalizes abnormal hippocampal glutaminase activity in APOE4 mice.
JHU-083
😃Good
Catalog No. T15613Alias JHU083Cas No. 1998725-11-3
JHU-083 is an orally available, blood-brain barrier-crossing, selective glutaminase antagonist that improves cognitive performance and normalizes abnormal hippocampal glutaminase activity in APOE4 mice.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 1-2 weeks | |
| 50 mg | $1,980 | 1-2 weeks | |
| 100 mg | $2,500 | 1-2 weeks |
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | JHU-083 is an orally available, blood-brain barrier-crossing, selective glutaminase antagonist that improves cognitive performance and normalizes abnormal hippocampal glutaminase activity in APOE4 mice. |
| In vivo | JHU-083 (1.82 mg/kg; orally; every other day for 12 days) was able to alleviate CSDS-induced social avoidance behaviors as well as behaviors resembling pleasure deprivation. JHU-083 (1.82 mg/kg; orally) reduced the magnitude of CSDS-induced enhancement of glutaminase activity in CD11b+ cells in the prefrontal cortex and hippocampus, but had no significant effect on cerebellar enzyme activity. In addition, JHU-083 treatment down-regulated the CSDS-induced expression levels of IL-1β and TNF-α. [1] |
| Alias | JHU083 |
| Molecular Weight | 312.37 |
| Formula | C14H24N4O4 |
| Cas No. | 1998725-11-3 |
| Smiles | [C@H](NC([C@H](CC(C)C)N)=O)(CCC(C=[N+]=[N-])=O)C(OCC)=O |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | PBS (pH 7.2): 20.00 mg/mL (64.03 mM), Sonication is recommended. DMSO: 80.00 mg/mL (256.11 mM), Sonication is recommended. Ethanol: 120.00 mg/mL (384.16 mM), Sonication is recommended. H2O: 30.00 mg/mL (96.04 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
PBS (pH 7.2)/H2O/DMSO/Ethanol
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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