Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator). It has nanomolar affinity (Kd = 1.7 nM) and a high modulatory potency (pEC50 = 7.71).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 8-10 weeks | $ 1,430.00 | |
50 mg | 8-10 weeks | $ 1,860.00 | |
100 mg | 8-10 weeks | $ 3,190.00 |
Description | JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator). It has nanomolar affinity (Kd = 1.7 nM) and a high modulatory potency (pEC50 = 7.71). |
Targets&IC50 | mGluR2:1.7 nM (kd) |
In vitro | Compared with WT, JNJ‐4628122 binds to the selected mGlu2?receptor mutants is significantly decreased by approximately 10‐fold. Mutations F643A and N735D are selected, in transfected mGlu2?WT and mutant receptors in CHO‐K1 cells [1]. |
Molecular Weight | 414.47 |
Formula | C23H25F3N4 |
CAS No. | 1254980-38-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 62.5 mg/mL (150.79 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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JNJ-46281222 1254980-38-5 Neuroscience GluR JNJ46281222 JNJ 46281222 inhibitor inhibit