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K-252a
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Catalog No. T15636Cas No. 99533-80-9
Alias SF2370, Antibiotic SF 2370, Antibiotic K 252a
K-252a is a staurosporine analog isolated from Nocardiopsis sp. soil fungi. K-252a inhibits protein kinase (IC50: 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively).
K-252a
😃Good
Catalog No. T15636Alias SF2370, Antibiotic SF 2370, Antibiotic K 252aCas No. 99533-80-9
K-252a is a staurosporine analog isolated from Nocardiopsis sp. soil fungi. K-252a inhibits protein kinase (IC50: 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $143 | 35 days | |
| 5 mg | $520 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | K-252a is a staurosporine analog isolated from Nocardiopsis sp. soil fungi. K-252a inhibits protein kinase (IC50: 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively). |
| Targets&IC50 | PKC:470 nM, CaMK II:270 nM, PhK:1.7 nM, PKA:140 nM |
| In vitro | K-252a is an effective inhibitor (IC50: 3 nM) of the tyrosine-protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk proto-oncogene [3]. |
| Alias | SF2370, Antibiotic SF 2370, Antibiotic K 252a |
| Molecular Weight | 467.47 |
| Formula | C27H21N3O5 |
| Cas No. | 99533-80-9 |
| Relative Density. | 1.67g/cm3 |
Storage & Solubility Information
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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