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Signaling PathwaysOthers-PROTACOthers-Target Protein Ligand-Linker ConjugateK-Ras ligand-Linker Conjugate 4
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K-Ras ligand-Linker Conjugate 4

K-Ras ligand-Linker Conjugate 4
K-Ras ligand-Linker Conjugate 4 is a chemical compound combining a K-Ras recruiting ligand with a PROTAC linker, responsible for recruiting E3 ligases such as VHL, CRBN, MDM2, and IAP. It has the potential to be used in synthesizing PROTAC K-Ras Degrader-1, which shows a degradation efficacy of ≥70% in SW1573 cells[1].
Catalog No. T18057Cas No. 2378261-83-5
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K-Ras ligand-Linker Conjugate 4

Catalog No. T18057Cas No. 2378261-83-5
K-Ras ligand-Linker Conjugate 4 is a chemical compound combining a K-Ras recruiting ligand with a PROTAC linker, responsible for recruiting E3 ligases such as VHL, CRBN, MDM2, and IAP. It has the potential to be used in synthesizing PROTAC K-Ras Degrader-1, which shows a degradation efficacy of ≥70% in SW1573 cells[1].
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Product Introduction

Bioactivity
Description
K-Ras ligand-Linker Conjugate 4 is a chemical compound combining a K-Ras recruiting ligand with a PROTAC linker, responsible for recruiting E3 ligases such as VHL, CRBN, MDM2, and IAP. It has the potential to be used in synthesizing PROTAC K-Ras Degrader-1, which shows a degradation efficacy of ≥70% in SW1573 cells[1].
In vitro
PROTACs consist of two distinct ligands linked together: one binds to an E3 ubiquitin ligase, and the other targets a specific protein. Utilizing the intracellular ubiquitin-proteasome system, PROTACs facilitate the selective degradation of target proteins[1].
Chemical Properties
Molecular Weight697.82
FormulaC35H51N7O8
Cas No.2378261-83-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Keywords

KRas ligandLinker Conjugate 4K Ras ligand Linker Conjugate 4K-Ras ligand-Linker Conjugate 4
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