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KIRA-7

Catalog No. T15664Cas No. 1937235-76-1

KIRA-7 is an imidazopyrazine compound. KIRA-7 has an anti-fibrotic effect. KIRA-7 binds the IRE1α kinase (IC50: 110 nM) to allosterically inhibit its RNase activity.

KIRA-7

KIRA-7

Catalog No. T15664Cas No. 1937235-76-1
KIRA-7 is an imidazopyrazine compound. KIRA-7 has an anti-fibrotic effect. KIRA-7 binds the IRE1α kinase (IC50: 110 nM) to allosterically inhibit its RNase activity.
Pack SizePriceAvailabilityQuantity
25 mg$1,3706-8 weeks
50 mg$1,7806-8 weeks
100 mg$2,8006-8 weeks
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Product Introduction

Bioactivity
Description
KIRA-7 is an imidazopyrazine compound. KIRA-7 has an anti-fibrotic effect. KIRA-7 binds the IRE1α kinase (IC50: 110 nM) to allosterically inhibit its RNase activity.
Targets&IC50
IRE1α kinase:110 nM
In vitro
In the alveolar epithelial cell line MLE12, KIRA-7 inhibits XBP1 splicing [1].
In vivo
After Bleomycin exposure, mRNA levels of BiP and CHOP are significantly elevated, and treatment of Bleomycin-exposed mice with KIRA-7 decreased these levels. KIRA-7 (5 mg/kg; intraperitoneal injection; daily for 14 days; C57BL6 mice) treatment causes decreased spliced XBP1 and ATF4, compared to bleomycin exposed mice treated with vehicle. mRNA levels of collagen 1A1 and fibronectin are both significantly decreased by KIRA-7 treatment [1].
Chemical Properties
Molecular Weight466.51
FormulaC27H23FN6O
Cas No.1937235-76-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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