Powder: -20°C for 3 years | In solvent: -80°C for 1 year
KP496 is a selective, dual antagonist for Thromboxane A2 receptor and Leukotriene D4 receptor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 8-10 weeks | $ 1,820.00 | |
50 mg | 8-10 weeks | $ 2,380.00 | |
100 mg | 8-10 weeks | $ 3,100.00 |
Description | KP496 is a selective, dual antagonist for Thromboxane A2 receptor and Leukotriene D4 receptor. |
In vivo | KP496 and prednisolone significantly suppress the increase of hydroxyl-L-proline content in the lung. Compare to respective vehicle control group, the inhibition ratio of KP496 and prednisolone for increase of hydroxyl-L-proline content is about 74 and 63%, respectively. The KP496 (100 mg/head) group and prednisolone (10 mg/kg) group exhibit significant inhibition of numbers of infiltrating total cells, eosinophils, monocytes/macrophages, and lymphocytes compare with the control group. Infiltration of all types of cells except neutrophils is decreased in the KP496 (30m g/head) group, though not to significant extents.KP496 significantly inhibits acute (day 7) and chronic (day 21) lung inflammation.?KP496 attenuates the number of lymphocytes on day 7 and those of macrophages, neutrophils, and eosinophils on days 7 and 21. |
Molecular Weight | 692.27 |
Formula | C31H34ClN3O7S3 |
CAS No. | 217799-03-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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KP496 217799-03-6 Others KP 496 KP-496 inhibitor inhibit