Powder: -20°C for 3 years | In solvent: -80°C for 1 year
KU 59403 is an effective ATM inhibitor (IC50: 3 nM, 9.1 μM, and 10 μM for ATM, DNA-PK, and PI3K, respectively).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 882.00 | |
50 mg | 10-14 weeks | $ 1,170.00 | |
100 mg | 10-14 weeks | $ 1,770.00 |
Description | KU 59403 is an effective ATM inhibitor (IC50: 3 nM, 9.1 μM, and 10 μM for ATM, DNA-PK, and PI3K, respectively). |
Targets&IC50 | ATM:3 nM |
In vitro | Inhibition of IR-induced ATM activity by KU 59403 (1 μM) is approximately 50% in MDA-MB231 cells and >50% in HCT116 cells that have low ATM expression and activity. KU 59403 (1 μM) increases VP-16 (1 μM) cytotoxicity to a similar extent in HCT116 and HCT116-N7 cells, and in the p53 mutant SW620 cells and human breast cancer cell line, MDAMB-231, sensitisation is 11.9±4.7 and 3.8±1.8-fold respectively [1]. |
In vivo | KU59403 with a single daily dose of 12.5 mg/kg induces an obvious sensitization. Increasing the dose of KU59403 to 25 mg/kg given twice daily causes the greatest chemo-sensitisation. In the absence of a significantly increased toxicity, It has a 3-fold increase in BMY-40481-induced tumour growth delay in both SW620 and HCT116-N7 xenografts [1]. |
Molecular Weight | 564.72 |
Formula | C29H32N4O4S2 |
CAS No. | 845932-30-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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KU 59403 845932-30-1 DNA Damage/DNA Repair PI3K/Akt/mTOR signaling ATM/ATR KU-59403 KU59403 inhibitor inhibit