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KU 59403

Catalog No. T15673   CAS 845932-30-1

KU 59403 is an effective ATM inhibitor (IC50: 3 nM, 9.1 μM, and 10 μM for ATM, DNA-PK, and PI3K, respectively).

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KU 59403 Chemical Structure
KU 59403, CAS 845932-30-1
Pack Size Availability Price/USD Quantity
25 mg 10-14 weeks $ 882.00
50 mg 10-14 weeks $ 1,170.00
100 mg 10-14 weeks $ 1,770.00
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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
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Biological Description
Chemical Properties
Storage & Solubility Information
Description KU 59403 is an effective ATM inhibitor (IC50: 3 nM, 9.1 μM, and 10 μM for ATM, DNA-PK, and PI3K, respectively).
Targets&IC50 ATM:3 nM
In vitro Inhibition of IR-induced ATM activity by KU 59403 (1 μM) is approximately 50% in MDA-MB231 cells and >50% in HCT116 cells that have low ATM expression and activity. KU 59403 (1 μM) increases VP-16 (1 μM) cytotoxicity to a similar extent in HCT116 and HCT116-N7 cells, and in the p53 mutant SW620 cells and human breast cancer cell line, MDAMB-231, sensitisation is 11.9±4.7 and 3.8±1.8-fold respectively [1].
In vivo KU59403 with a single daily dose of 12.5 mg/kg induces an obvious sensitization. Increasing the dose of KU59403 to 25 mg/kg given twice daily causes the greatest chemo-sensitisation. In the absence of a significantly increased toxicity, It has a 3-fold increase in BMY-40481-induced tumour growth delay in both SW620 and HCT116-N7 xenografts [1].
Molecular Weight 564.72
Formula C29H32N4O4S2
CAS No. 845932-30-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Batey MA, et al. Preclinical evaluation of a novel ATM inhibitor, KU59403, in vitro and in vivo in p53 functional and dysfunctional models of human cancer. Mol Cancer Ther. 2013 Jun;12(6):959-67.

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Keywords

KU 59403 845932-30-1 DNA Damage/DNA Repair PI3K/Akt/mTOR signaling ATM/ATR KU-59403 KU59403 inhibitor inhibit

 

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