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LY309887

Catalog No. T15813 CAS 127228-54-0

LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (Ki: 6.5 nM). It also has antitumor activity.

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LY309887, CAS 127228-54-0

Pack Size	Availability	Price/USD
25 mg	10-14 weeks	$ 1,400.00
50 mg	10-14 weeks	$ 1,820.00
100 mg	10-14 weeks	$ 2,810.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

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Description	LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (Ki: 6.5 nM). It also has antitumor activity.
Targets&IC50	GARFT:(ki)6.5 nM, FRβ:18.2 nM(ki), FRα:1.78 nM(ki)
In vitro	LY309887 is significantly cytotoxic against the human leukemia cell line CCRF-CEM (IC50: 9.9 nM). LY309887 also has high affinity at human folate receptor (FR)α and FRβ (Ki, 1.78 nM, and 18.2 nM, respectively) .
In vivo	In mice bearing C3H mammary cancer cells, LY309887 (3 mg/kg-100 mg/kg, i.p.) displays complete inhibition on the tumor growth.

Molecular Weight	449.48
Formula	C19H23N5O6S
CAS No.	127228-54-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Mendelsohn LG, et al. Biochemistry and pharmacology of glycinamide ribonucleotide formyltransferase inhibitors: LY309887 and lometrexol. Invest New Drugs. 1996;14(3):287-94.

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Keywords

LY309887 127228-54-0 Immunology/Inflammation LTR LY 309887 LY-309887 inhibitor inhibit

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