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ML241

Catalog No. T3164   CAS 1346528-06-0

ML241 is a potent and selective inhibitors of p97 ATPase.

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ML241 Chemical Structure
ML241, CAS 1346528-06-0
Pack Size Availability Price/USD Quantity
5 mg 4-6 weeks $ 78.00
10 mg 4-6 weeks $ 126.00
25 mg 4-6 weeks $ 277.00
50 mg 4-6 weeks $ 468.00
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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
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Biological Description
Chemical Properties
Storage & Solubility Information
Description ML241 is a potent and selective inhibitors of p97 ATPase.
Kinase Assay EPZ015666 is serially diluted threefold from 1,000 to 0.051 nM and spotted into a 384-well polypropylene V-bottom microplate. 3H-SAM is serially diluted twofold in assay buffer for a seven-point dilution series with a top concentration of 700 nM (final assay concentration). Reactions are initiated by the addition of 4 nM enzyme and 40 nM peptide (final assay concentrations for both). Reactions are incubated for 60 min and quenched by the addition of 10 μL per well of 600 μM unlabeled SAM in assay buffer (final assay concentration). For the peptide competition, EPZ015666 is serially diluted threefold from 1,000 to 0.051 nM and spotted into a 384-well polypropylene V-bottom microplate. Peptide is serially diluted twofold in assay buffer for a seven-point dilution series with a top concentration of 480 nM (final assay concentration). Reactions are initiated by the addition of 4 nM enzyme and 75 nM 3H-SAM (final assay concentrations for both). Reactions are incubated for 60 min, and the reactions are quenched by the addition of 10 μL per well of 600 μM unlabeled SAM in assay buffer (final assay concentration)[1].
Molecular Weight 372.46
Formula C23H24N4O
CAS No. 1346528-06-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mM

TargetMolReferences and Literature

1. Chou TF, et al.ChemMedChem. 2013 Feb;8(2):297-312.

Related Products

Related compounds with same targets
CB-5083 MNS DBEQ UPCDC30766 CB-5339 ML241 hydrochloride NMS-873 ML240

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

ML241 1346528-06-0 Ubiquitination p97 ML 241 ML-241 inhibitor inhibit

 

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