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MSC1094308

Name: MSC1094308
Brand: TargetMol
SKU: T12114
Rating: 4.5 (1 reviews)

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Catalog No. T12114Cas No. 2219320-08-6

Alias MSC 1094308

MSC1094308 is a reversible, non-ATP-competitive alterative inhibitor targeting type II AAA ATPase (VCP/p97) and type I AAA ATPase (VPS4B), which affects the intracellular protein degradation process by binding to a specific hotspot region of p97 and inhibiting D2 ATPase activity.

MSC1094308

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Catalog No. T12114Alias MSC 1094308Cas No. 2219320-08-6

Pack Size	Price	Availability	Quantity
2 mg	$308	5 days

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COA

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	MSC1094308 is a reversible, non-ATP-competitive alterative inhibitor targeting type II AAA ATPase (VCP/p97) and type I AAA ATPase (VPS4B), which affects the intracellular protein degradation process by binding to a specific hotspot region of p97 and inhibiting D2 ATPase activity.
Targets&IC50	VPS4B:0.71 μM, p97:7.2 μM
In vitro	Treatment of HCT116 cells with MSC1094308 (10 μM, 8 hours) can induce intracellular accumulation of polyubiquitin, a biomarker that can be used as a degradation inhibitor in HCT116 cells. [1]
Alias	MSC 1094308

Chemical Properties

Molecular Weight	462.55
Formula	C₂₉H₂₉F₃N₂
Cas No.	2219320-08-6
Smiles	FC1=CC=C(C=C1)C(C2=CC=C(F)C=C2)CCCNCC3CC=4C=5C=C(F)C=CC5NC4CC3
Relative Density.	1.211 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 40 mg/mL (86.48 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1619 mL	10.8096 mL	21.6193 mL	108.0964 mL
5 mM	0.4324 mL	2.1619 mL	4.3239 mL	21.6193 mL
10 mM	0.2162 mL	1.0810 mL	2.1619 mL	10.8096 mL
20 mM	0.1081 mL	0.5405 mL	1.0810 mL	5.4048 mL
50 mM	0.0432 mL	0.2162 mL	0.4324 mL	2.1619 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc