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MPT0B392
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Catalog No. T13779Cas No. 1346169-92-3
MPT0B392 is an orally active quinoline derivative, induces c-Jun N-terminal kinase (JNK) activation.
MPT0B392
😃Good
Catalog No. T13779Cas No. 1346169-92-3
MPT0B392 is an orally active quinoline derivative, induces c-Jun N-terminal kinase (JNK) activation.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,270 | 6-8 weeks | |
| 50 mg | $1,650 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | MPT0B392 is an orally active quinoline derivative, induces c-Jun N-terminal kinase (JNK) activation. |
| In vitro | MPT0B392 induces apoptosis in HL60 cancer cells[1]. MPT0B392 (0.1 μM for 6-48 hours; 0.01-0.1 μM for 24 and 48 hours) triggers cells arrest in the G2/M phase, followed by accumulation in subG1 phase in a concentration and time-dependent manner[1]. MPT0B392 (0.1 μM; 48 hours) increases the phosphorylation of Bcl-2, Mcl-1S and decreases in Mcl-1L[1]. |
| In vivo | MPT0B392 shows relative potent anti-leukemia activity in a vivo xenograft model[1]. |
| Molecular Weight | 404.44 |
| Formula | C19H20N2O6S |
| Cas No. | 1346169-92-3 |
| Relative Density. | 1.332 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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